Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells

By Chandrashekhar Pasare, R. Medzhitov. Science, 2003

2,321 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/84336cd0fa9ff7eec49a410b2595c7c260ac2507

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In Immunology

1. D. Cua
2. Shimon Sakaguchi
3. R. Flavell
4. Dan R. Littman
5. V. Kuchroo
6. Y. Belkaid
7. E. Shevach
8. R. Medzhitov

Citations in the corpus

• Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma (2005, background): “Current evidence indicates that naturally occurring T Reg cells and IL-10-secreting regulatory T cells have the capacity to regulate low-grade inflammation independently of cytokines, whereas suppressive cytokines (such as IL-10 and TGF-β) might be required to regulate more acute inflammation on ac”
• Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells (2004, background): “CD4 cells unresponsive to the Treg-mediated immunosuppression (30).”
• Recognition of microbial infection by Toll-like receptors. (2003, background): “MyD88 and other intracellular signaling molecules The MyD88-dependent pathway is critical to the production of inducible inflammatory cytokines, such as IL-12, TNF and IL-6.”
• Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection (2007, background): “Interestingly, because previous studies have demonstrated an inhibitory eff ect of TLR signaling on CD25+CD4+ T reg cell activity (54), their functional capacity may be limited during infection with agents such as T.”
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation (2005, background): “IL-6 produced by LPS-activated dendritic cells can turn off regulatory T cell (T reg cell) function, allowing effector T cell activation ( 35 ).”
• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “Joffre, unpublished data), unlike their directly activated counterparts (107).”
• Immunosuppressive networks in the tumour environment and their therapeutic relevance (2005, background): “Notably, IL-6 can promote B-cell differentiation and has been suggested to block the suppressive activity of REGULATORY T CELLS (T Reg cells”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “TLRs may also play a role in mechanisms of immune suppression by regulatory T lymphocytes and in humoral immune responses mediated by B lymphocytes (48, 289, 290).”
• Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement (2006, background): “Indeed, even during periods of health, the gut lumen is the site of a large population of bacteria, which under normal conditions contribute to the viability of the host (1, 2).”