Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

By S. Rhee, Y. Bae, Seung-Rock Lee, J. Kwon. Science's STKE, 2000

743 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/83f088aed1a6b230558688197aaccc3eca57992d

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Citations in the corpus

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. (2005, background): “Many nonphagocytic cell types, however, are now known to produce H2O2 in response to a variety of extracellular stimuli such as cytokines, neurotransmitters, peptide growth factors and hormones [2–5].”
Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “Others have shown that many of the responses to growth factors, hormones and inflammatory cytokines involve redox signalin”
Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB1 (2004, background): “tivities including host defense and metabolic conversions (10).”
Peroxiredoxin, a Novel Family of Peroxidases (2001, background): “Although H 2 O 2 is generally considered a toxic by-product of respiration, increasing evidence suggests that the production of H 2 O 2 might be an integral component of membrane receptor signaling ( 32 ).”
Cell Signaling during Cold, Drought, and Salt Stress Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.000596. (2002, background): “Similar approaches may prove useful for the study of Representative cascades, outputs, biological functions, and examples of mutants with phenotypes indicative of defects in the respective biological functions are shown.”
Nitric oxide and redox mechanisms in the immune response (2011, background): “PTPs contain cysteinyl residues in their catalytic site, which when oxidized by ROS, results in inactivation of the phosphatase [217, 218].”
Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants (2013, background): “H2O2 is recognized as an ubiquitous intracellular messenger [75–78].”
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. (2008, background): “ROS can act as a signaling molecule for activation of diverse signaling pathways by oxidation of reactive cysteine on the specific target molecules including kinases, phosphatases [28,30], redox-sensitive transcription factors [112], cell cycle regulators [113].”
Oxidative Stress, Prooxidants, and Antioxidants: The Interplay (2014, background): “The role of hydrogen peroxide in promoting phosphatase inactivation by cysteine oxidation provided a likely biochemical mechanism by which ROS can impinge on signaling pathways [67].”
Reactive oxygen species in cancer (2010, background): “H2O2 regulates protein activity through reversible oxidation of its targets including protein tyrosine phosphatases, protein tyrosine kinases, receptor tyrosine kinases and transcription factors [1, 27, 58].”
Molecular and Structural Basis for Redox Regulation of β-Actin (2007, background): “56 An initial oxidative burst would first have to overcome such oxidative defenses and necessitate amplification.(57) However, a H2O2 gradient may also have differential oxidative effects of functional relevance, leading to dimer formation, glutathionylation, and depolymerization in the actin system”
Mitochondrial DNA: more than an evolutionary bystander (2014, background): “Soon thereafter, it was reported that hydrogen peroxide could promote phosphatase inactivation by cysteine oxidation and provided a plausible biochemical mechanism by which ROS can impinge on signalling pathways (Rhee et al. 2000).”