Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB1

By H. Park, H. Jung, E. Park, Jaesang Kim, W. Lee, Y. Bae. Journal of Immunology, 2004

666 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Nox family NADPH oxidases: Molecular mechanisms of activation. (2014, background): “and TLR4 has been reported as well as an acute increase in ROS formation by Nox4 in this model [170].”
Radical-free biology of oxidative stress. (2008, background): “10) Similarly, mitochondrial and nonmitochondrial production of H2O2 in response to LPS activation of Toll-like receptor-4 provides additional sites of redox sensitivity (77, 139).”
Ferroptosis in infection, inflammation, and immunity (2021, background): “In addition to its immunomodulatory roles, TLR4 may also directly promote cell death (including apoptosis and ferroptosis) by binding to NOX4 or its isoenzymes (Park et al., 2004).”