Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

By A. Rahal, Amit Kumar, Vivek Singh, B. Yadav, R. Tiwari, S. Chakraborty, Kuldeep Dhama. BioMed Research International, 2014

1,602 citations recorded by the source corpus.

Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme systems participating in the in vivo redox homeostasis. Therefore, oxidative stress can also be viewed as an imbalance between the prooxidants and antioxidants in the body. For the last two decades, oxidative stress has been one of the most burning topics among the biological researchers all over the world. Several reasons can be assigned to justify its importance: knowledge about reactive oxygen and nitrogen species production and metabolism; identification of biomarkers for oxidative damage; evidence relating manifestation of chronic and some acute health problems to oxidative stress; identification of various dietary antioxidants present in plant foods as bioactive molecules; and so on. This review discusses the importance of oxidative stress in the body growth and development as well as proteomic and genomic evidences of its relationship with disease development, incidence of malignancies and autoimmune disorders, increased susceptibility to bacterial, viral, and parasitic diseases, and an interplay with prooxidants and antioxidants for maintaining a sound health, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue.

Subfields: Biochemistry, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/4d94db6f68f554c2b96ef22f6fc186d6b384385e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Shrikant Kukreti
2. Anju Singh
3. R. Kukreti
4. L. Saso
5. E. Kurutaş

In Molecular Biology

1. Shrikant Kukreti
2. D. Tuveson
3. Anju Singh
4. I. I. C. Chio
5. C. Tonelli
6. R. Kukreti
7. L. Saso
8. E. Kurutaş

In Nutrition and Dietetics

1. E. Kurutaş

Citations in the corpus

• Phenolic Compounds in Honey and Their Associated Health Benefits: A Review (2018, background): “Free radicals and reactive oxygen species (ROS) are the major oxidant agents in cellular systems, and they are involved in aging and in the onset of many kind of diseases [44].”
• Transcriptional Regulation by Nrf2 (2017, background): “At high levels, these toxicants can cause damage to cellular components, including proteins, lipids, and DNA (133).”
• ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “Increased expression of catalase and peroxiredoxin 1 molecules are considered as OS markers [20–22].”
• The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “Moreover, α-lipoic acid exerts a protective effect on the kidney of diabetic rats but a prooxidant effect in nondiabetic animals [189].”
• Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “Because it is clear that, along with antioxidants, pro-oxidants also play crucial role in oxidative stress and diseases, the awareness around pro-oxidants is equally important to combat OS and neurodegeneration [40,41].”