Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

By H. Jin, A. Anderson, W. Tan, E. West, S. Ha, K. Araki, G. Freeman, V. Kuchroo, Rafi Ahmed. Proceedings of the National Academy of Sciences of the United States of America, 2010

882 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/8457256232f57d30d450348e72e3f9bd9c9b3663

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Citations in the corpus

DE NOVO EPIGENETIC PROGRAMS INHIBIT PD-1 BLOCKADE-MEDIATED T-CELL REJUVENATION (2017, neutral): “Recent efforts to identify antigen-specific CD8 T cells that retain the potential to respond to ICB therapy have established that the cumulative expression of multiple inhibitory receptors progressively restricts the cells’ ability to be rejuvenated (Jin et al., 2010).”
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints (2016, background): “…Immunology and Infectious Disease literature have shown that TIM-3 is co-expressed with PD-1 in exhausted T cells in the context of anti-microbial responses 26–29 , which support our ﬁnding of TIM-3 expression on therapeutic anti-PD-1 antibody-bound T cells in the setting of treatment failure.”
Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T Cell Rejection Function in Tumors (2013, background): “Co-expression of more than one receptor by CD8 T cells has been correlated with a more severe exhausted phenotype (39-42).”
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells (2015, neutral): “…its versatility, NFAT forms dimers on palindromic kB-like sequence elements and can bind DNA as a monomer (Chen et al., 1998; Giffin et al., 2003; Jin et al., 2010; Stroud et al., 2002); it also forms cooperative complexes with FOXP3, a transcription factor central to T cell regulatory function…”
Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging (2018, result): “It has been postulated that multi-IR expression by individual T cells reflects more advanced immune exhaustion (104) in agreement with reports of T cells in virally infected mice (63, 105).”