Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

By Ming O. Li, Shomyseh Sanjabi, R. Flavell. 2006

754 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/83d2537eea79c90fb207e3c79b6b4c4c11b37bf8

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Citations in the corpus

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “A TGF-β-regulated transcription factor, T-bet, is responsible for Th1 differentiation and survival of activated CD4+ T cells via mediating CD122 expression and IL-15 signaling in Th1 cells [250].”
A two-step process for thymic regulatory T cell development. (2008, result): “Although TGF-b has been suggested to be important for the development of Foxp3+ cells from peripheral T cells in vitro (Chen et al., 2003), we did not observe a role for TGF-b in our in vitro thymocyte assay (Figure S5), consistent with in vivo observations from conditional T cell knockouts of TGF-b”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “TGF-β1 deficient mice develop T cell-mediated autoimmunity within several weeks after birth (Li et al., 2006b).”
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “…types produce and respond to TGF-β1, there is evidence that CD4+ T cells are required as both producers and responders for intact intestinal immune regulation which may reflect the ability of TGF-β1 to induce the peripheral development of Foxp3+ Treg cells (Li and Flavell, 2008; Li et al., 2006).”
TGF-beta: a master of all T cell trades. (2008, positive): “T cell phenotype and did not differentiate into T helper 1 (Th1) or Th2 effector T cells (Li et al., 2006a).”
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008, background): “Mixed–bone marrow chimera experiments showed that this syndrome was also distinct from T reg cell deficiencies arising from loss of IL-2 or transforming growth factor-β signalin”
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. (2007, background): “These ﬁndings are also of interest in that TGF-b 1 is important for maintenance peripheral regulatory T (Treg) cells (Li et al., 2006; Marie et al., 2006).”