Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
By D. Ryu, L. Mouchiroud, P. Andreux, E. Katsyuba, N. Moullan, Amandine A Nicolet-dit-Félix, Evan G. Williams, Pooja Jha, G. Lo Sasso, Damien Huzard and 4 more. Nature Medicine, 2016
930 citations recorded by the source corpus.
Subfields: Aging, Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/83462ccf03bd23b590838b5687b417836809de06
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In Aging
In Molecular Biology
Citations in the corpus
- Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “142,143 14 With age, there is a decrease in the protein levels required for mitochondrial fi ssion.”
- Measuring biological aging in humans: A quest (2019, background): “Urolithin A has been shown to induce mitophagy in cell cultures, increase longevity in nematodes, and prevent age-related muscle impairment in mouse models (Ryu et al., 2016).”
- Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, background): “enhancer, a dietary, flora-derived metabolite which can enhance muscle strength and endurance as well as mitochondrial and muscle function during aging [186].”
- Molecular mechanisms and physiological functions of mitophagy (2021, positive): “Pharmacological screens to identify chemical agents to modulate elimination of mitochondria are ongoing, and several synthetic and natural chemical compounds including Urolithin A have been shown to facilitate mitophagy (Ryu et al , 2016).”
- The mitophagy pathway and its implications in human diseases (2023, background): “Urolithin A can activate mitophagy to improve neuroinflammation and delay aging.(365,366) A clinical trial of urolithin A in immune health is currently recruiting patients (NCT05735886).”