The cornified envelope: a model of cell death in the skin

By E. Candi, R. Schmidt, G. Melino. Nature reviews. Molecular cell biology, 2005

1,824 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/7fec278b33ed54552426aeec3f2b2ff3f7dec1b5

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Citations in the corpus

Classification of cell death (2005, neutral): “, UV irradiation), cornification is exclusive of the upper layers (granular layer and stratum corneum).(17,18)”
Fingermarks, more than just a ridge pattern (2014, background): “The process of cell renewing takes approximately 28 days [8, 11].”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “which are extruded into the extracellular space and covalently attached to cornified envelope proteins to ensure skin impermeability.(166) The skin of Casp14 / mice presents an”
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation (2011, background): “Additionally, other proteins encoded by genes in the EDC discussed above including loricrin and involucrin are essential components of the epidermal barrier (60).”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “isoforms of transglutaminase [1025, 1028, 1029], has long been considered as a form of PCD [1025, 1030].”
p63 is upstream of IKKα in epidermal development (2006, background): “Introduction The epidermis is a multi-layered, stratified epithelium continuously regenerated by terminally differentiating keratinocytes (Candi et al., 2005; Fuchs and Watt, 2003; Owens and Watt, 2003), in which a major role is played by p63 (Yang et al.”
Epidermal barrier dysfunction in atopic dermatitis. (2009, background): “During terminal differentiation, KCs replace their plasma membrane with an insoluble protein layer referred to as the ‘‘cornified envelope’’ (CE) (Candi et al., 2005).”
Epidermal stem cells of the skin. (2006, background): “The cornified envelope seals the epidermal squames and provides the barrier that keeps microbes out and essential fluids in (Candi et al. 2005, Fuchs 1995) (Figure 1).”
Mammalian lipoxygenases and their biological relevance (2014, background): “These reactive lipids may subsequently be linked covalently to proteins contributing to the formation of the cornified envelope [88, 89].”
Consensus guidelines for the detection of immunogenic cell death (2014, neutral): “For the sake of precision, it should be noted that the latter system does not detect CALR-GFP exposure in itself, but the ER perinuclear clustering that invariably accompanies exposure.(20,232) We have also successfully employed a PDIA3-specific antibody and flow cytometry as well as PDIA3-GFP-expre”
Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “Although squamous cells are eventually shed from the skin surface and are replaced by differentiating cells from below, they briefly serve as the barrier that keeps harmful microbes out and essential body fluids i”