Molecular machinery for non-vesicular trafficking of ceramide

By K. Hanada, Keigo Kumagai, S. Yasuda, Yukiko Miura, M. Kawano, M. Fukasawa, M. Nishijima. 2003

1,052 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Futerman
2. Yusuf A. Hannun
3. LM Obeid
4. B. Ogretmen
5. Michal Levy
6. S. Milstien
7. Sarah Spiegel
8. S. Saddoughi

In Molecular Biology

1. A. Futerman
2. Yusuf A. Hannun
3. B. Ogretmen
4. Michal Levy
5. LM Obeid
6. Sarah Spiegel
7. S. Saddoughi
8. P. Song

Citations in the corpus

• Mammalian Ceramide Synthases (2010, background): “While de novo ceramide synthesis occurs in the ER, further metabolism to sphingomyelin and glycosphingolipids occurs in the Golgi apparatus (3), with ceramide being transported from the ER to the Golgi apparatus by either vesicular trafficking or by the ceramide transfer protein, CERT (6).”
• Lipid map of the mammalian cell (2011, background): “Golgi synthesis of glucosylceramide was shown to be CERT independent (Hanada et al., 2003) (cf.”
• Bi-directional protein transport between the ER and Golgi. (2004, background): “In addition, some lipid species such as ceramide can reach the Golgi through a nonvesicular route (Funato & Riezman 2001, Hanada et al. 2003).”
• Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide (2006, methodology): “Hence, we named the cDNA product CERT (standing for ceramide transport) [28].”
• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “lar transport (Hanada et al., 2003).”
• A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. (2013, positive): “MCSs between the ER and the Golgi contain the following lipid transporters: CERT, which transports ceramide (Hanada et al., 2003); FAPP2, which transports glucosylceramide (D’Angelo et al., 2007); Sec14/Nir2, which transports phosphatidylinositol (Litvak et al., 2005); and OSBP, which might…”
• The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus. (2004, background): “These domains have been proposed to play a role in non-vesicular transport of ceramide [20] but this may not be their exclusive function.”
• The complex life of simple sphingolipids (2004, background): “…long chain base (normally sphingosine, sphinganine or 1Department of Biological Chemistry,Weizmann Institute of Science,Rehovot 76100,Israel 2Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425-2211, USA +Corresponding author.”
• Principles of bioactive lipid signalling: lessons from sphingolipids (2008, background): “The ceramide transfer protein CERT has been shown to effect ceramide transport from its site of synthesis in the endoplasmic reticulum (ER) to the Golgi and to be required for synthesis of SM (but not for glucosylceramide synthesis”
• Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “1), which requires the transport of ceramide from the endoplasmic reticulum (ER) to the Golgi apparatus by ceramide transporter protein, CERT, via non-vesicular transport (Hanada et al., 2003; Kumagai et al., 2005; Rao et al., 2007; Kudo et al., 2008).”
• Phospholipid Synthesis and Transport in Mammalian Cells (2015, background): “Some studies indicate that PC import into mitochondria from the ER requires the steroidogenic Traffic 2015; 16: 1–18 13 acute regulatory protein, StarD7-1 (104), which, intriguingly, contains a START motif similar to the START lipid transfer sequence that is present in both the ceramide transfer pro”