Principles of bioactive lipid signalling: lessons from sphingolipids

By Yusuf A. Hannun, LM Obeid. Nature reviews. Molecular cell biology, 2008

3,308 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ac44b21ddf1227f91184c22c682582cec50725c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. J. Sampaio
2. LM Obeid
3. K. Simons
4. Yusuf A. Hannun
5. L. Pike
6. B. Ogretmen
7. C. Dart
8. A. Futerman

In Molecular Biology

1. Brent R. Stockwell
2. J. Sampaio
3. M. Gaschler
4. W. Yang
5. K. Simons
6. M. Shchepinov
7. Yusuf A. Hannun
8. LM Obeid

Citations in the corpus

• Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “Sphingolipids contain acyl chains coupled to serine and polar head groups derived from ethanolamine, serine or choline (Hannun and Obeid, 2008).”
• THE ALLIANCE OF SPHINGOSINE-1-PHOSPHATE AND ITS RECEPTORS IN IMMUNITY (2008, background): “Two sphingosine kinases ( SPHK1 and SPHK2 ) then phosphorylate sphingosine to generate the lysosphingolipid sphingosine-1-phosphate (S1P”
• Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing (2009, neutral): “of their central role in cell signaling, and as potential drug targets for cancer and other human diseases, there is a great deal of interest in thesemolecules, and thus there is a corresponding level of interest in the regulation of the enzymes that are responsible for their synthesis and degradati”
• An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “It has been shown repeatedly that ceramide has distinct signaling properties from dihydroceramide and phytoceramide, suggesting that, if nothing else, cells have evolved to recognize ceramide as a more significant determinant to initiate a cellular response to in most cells [35].”
• Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry (2009, methodology): “Finally, we note that minor modifications of the methodology should enable the characterization of mammalian glycosphingolipids, bioactive LPA and LCBP species (33, 34) and phosphoinositides (35).”
• Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis (2016, background): “Ceramide has been implicated in cell death following activation of stress responses (24, 25).”