Mammalian Ceramide Synthases

By Michal Levy, A. Futerman. 2010

608 citations recorded by the source corpus.

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases. © 2010 IUBMB IUBMB Life, 62(5): 347–356, 2010

Subfields: Molecular Biology, Organic Chemistry, Computational Biology & Bioinformatics

Citations in the corpus

• Accurate prediction of protein structures and interactions using a 3-track neural network (2021, neutral): “The RoseTTAFold CERS1 model for residues 98 to 304 (Pfam TLC domain) ( 29 ) includes six TMH that traverse the membrane in an up and down arrangement (Fig.”