A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.

By B. Mesmin, J. Bigay, Joachim Moser von Filseck, S. Lacas‐Gervais, Guillaume Drin, Bruno Antonny. Cell, 2013

712 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cc46a86448d450ecd78f71d0c7dfec06213eefa9

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In Molecular Biology

1. R. Rad
2. M. Sowa
3. Edward L. Huttlin
4. M. Wühr
5. J. Harper
6. Steven P. Gygi
7. S. Artavanis-Tsakonas
8. A. Ordureau

Citations in the corpus

• The BioPlex Network: A Systematic Exploration of the Human Interactome (2015, background): “In contrast, expression of aggregation-prone VAPBP56S led to recruitment of EGFP-LSG1, but not of OSBP, into the aggregates (Figures 7F and 7H).”
• Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles (2016, background): “The observation that replication is hampered when PI4P transported to the ER is not hydrolyzed upon knockdown of Sac1 [23,60] underscores the importance of the cholesterol/PI4P-counterflux for enterovirus replication.”