Direct observation of ligand recognition by T cells

By D. Irvine, M. Purbhoo, M. Krogsgaard, Mark M. Davis. Nature, 2002

866 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7fcd80698343b025aa5f22a35ddde3b0dce929e3

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In Immunology

Citations in the corpus

T cell killing does not require the formation of a stable mature immunological synapse (2004, background): “These limitations have been overcome by direct imaging on live cells of individual fluorescence-labeled pMHC class II complexes at the T cell–APC interfac”
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. (2006, background): “…signaling based upon the central concentration of the tyrosine kinase Lck (Ehrlich et al., 2002; Monks et al., 1998), phosphatidylinositol-3-kinase products (Costello et al., 2002; Huppa et al., 2003), and selfMHCp that participate in signaling (Irvine et al., 2002; Krogsgaard et al., 2005).”
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation (2009, background): “Thus, given the short half-life of most TCR-ligand interactions and the relatively few ligands required for T cell activatio”
T-cell-antigen recognition and the immunological synapse (2003, background): “An important recent advance has been the development of a new approach that provides more precise information about T-cell sensitivity and the nature of T-cell responsiveness to different numbers of ligand”
Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes (2009, background): “of complexes between MHC and self peptides derived from proteins of the host cell [95, 96].”
CD28-mediated co-stimulation: a quantitative support for TCR signalling (2003, background): “As discussed earlier, under normal circumstances, only a few TCRs are ligated at once, a condition likely to generate short-lasting/incomplete activation event”