T cell killing does not require the formation of a stable mature immunological synapse

By M. Purbhoo, D. Irvine, J. Huppa, Mark M. Davis. Nature Immunology, 2004

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Remote control of therapeutic T cells through a small molecule-gated chimeric receptor (2015, background): “Relative to cytokine production and proliferation, T cell–mediated cell killing occurs on a faster time scale (minutes) and with different thresholds (42, 43).”
Formation and function of the lytic NK-cell immunological synapse (2008, background): “Furthermore, single molecule studies and kinetic studies of the immunological synapse have shown that, in some settings, the engagement of individual receptor”
Death by a thousand cuts: granzyme pathways of programmed cell death. (2008, background): “However, the organization of granule fusion at the synapse may differ among types of killer cells, and cytotoxicity and granule fusion may occur even in the absence of a stable synapse (62).”
Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes (2009, background): “of complexes between MHC and self peptides derived from proteins of the host cell [95, 96].”