CD28-mediated co-stimulation: a quantitative support for TCR signalling

By Oreste Acuto, F. Michel. Nature reviews. Immunology, 2003

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T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5–positive CD4 cells and germinal centers.”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “IS CD28 SIGNALING AFFECTED IN Tcons UPON SUPPRESSION BY Tregs? Proliferation and activation of T cells does not only require TCR stimulation but also a second, costimulatory signal (Acuto and Michel, 2003).”
CD28 and CTLA-4 coreceptor expression and signal transduction (2009, background): “The importance of cell intrinsic regulation has come from studies showing that coligation of the coreceptor with TCR can induce anergy (21, 22) and, secondly, that transgenic expression of CTLA-4 lacking the cytoplasmic domain on a Ctla4 ⁄ ) background does not restore a normal phenotype as observed”