T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

By R. Varma, G. Campi, T. Yokosuka, T. Saito, Michael Loran Dustin. Immunity, 2006

867 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9b087cc347cdb6435d2db3f00dc1b88bc518fd6c

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In Immunology

1. M. Azuma
2. J. Orange

Citations in the corpus

• Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 (2012, methodology): “PD-1–EGFP were prestained with a fluorescence-labeled anti–TCR- (H57) Fab fragment (Varma et al., 2006) and imaged by confocal microscopy.”
• Formation and function of the lytic NK-cell immunological synapse (2008, background): “In T cells, TCR signalling stems from microclusters of TCR molecules that move from the pSMAC to the cSMAC as activation proceed”