Mucosal flora in inflammatory bowel disease.

By A. Swidsinski, A. Ladhoff, A. Pernthaler, S. Swidsinski, V. Loening-Baucke, M. Ortner, J. Weber, U. Hoffmann, Stefan Schreiber, M. Dietel and 1 more. Gastroenterology, 2002

1,392 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7fbc8d0153e1ae8331900e72eb7c0ea11db4dc5c

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Citations in the corpus

Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “haps also systemic, immune disorders, such as in the pathogenesis of inflammatory bowel diseases (IBD), and other gastrointestinal disorders, including gastritis, peptic ulcer, irritable bowel syndrome (IBS) and even gastric and colon cancer [14,31-33].”
High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease (2011, background): “Faecal stream diversion induces remission in CD [13], animal models of colitis require the presence of gut bacteria to initiate inflammation (reviewed in [14]), an increased mucosal bacterial load is observed in IBD patients [15,16], genome-wide IBD association studies have identified polymorphisms ”
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis (2006, background): “Each of these situations has been documented in Crohn's disease patients”
Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease (2004, background): “44 51 Detection of these species in the larger SSCP experiment microflora represents the interindividual variability of the bacterial microflora of a high number of patients compared with the cloning experiment.”
Intestinal microbiota in human health and disease: the impact of probiotics (2011, positive): “Bifidobacterium, Clostridium histolyticum, C. Table 4 continued Study material Population Analytical methods Key findings References Faeces (2 time points) 31 Monozygotic twin pairs 23 Dizygotic twin pairs 46 Mothers of twin pairs Sanger sequencing (16S) 454 FLX titanium sequencing (metagenome) Most”
The gut microbiota and inflammatory bowel disease (2014, positive): “The mucosa-associated microbiota is increased in IBD compared with healthy subjects [22, 23].”
NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression (2004, background): “demonstrated that the diseased epithelium may display attaching and even invading bacteria whereas normal mucosa handled under the same conditions is virtually sterile.”
Mechanisms of action of probiotics: Recent advances (2009, background): “Antimicrobial activities of probiotics include the (1) production of bacteriocins/defensins, (2) competitive inhibition with pathogenic bacteria, (3) inhibition of bacterial adherence or translocation, and (4) reduction of luminal pH.”
Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease (2005, methodology): “Using microbial culture validated by quantitative PCR with subsequent cloning and sequencing, we have previously shown that colon biopsy specimens from healthy humans without IBD are nearly free of bacteria once they are washed of fecal contents (31).”