Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
By R. Sartor. Nature Clinical Practice Gastroenterology &Hepatology, 2006
1,834 citations recorded by the source corpus.
Subfields: Epidemiology, Genetics, Surgery
View Paper: https://www.semanticscholar.org/paper/095021c65aef33d262a46c58719894236e327e71
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In Epidemiology
In Genetics
- Levi Waldron
- B. B. Finlay
- Curtis Huttenhower
- Gary D. Wu
- L. Antunes
- I. Sekirov
- Dirk Gevers
- Shannon L. Russell
In Surgery
- Peter D. Siersema
- Levi Waldron
- B. B. Finlay
- Curtis Huttenhower
- Dirk Gevers
- W. Garrett
- Nicola Segata
- Y. Belkaid
Citations in the corpus
- Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease (2015, background): “…results from a pathologic interaction between the mucosal immune system and the environment, particularly the microbes residing in the gut lumen (Sartor, 2006, 2008) and is characterized by altered—or “dysbiotic”--gut bacterial composition (Huttenhower et al., 2014; Khor et al., 2011; Sartor,…”
- Critical review: vegetables and fruit in the prevention of chronic diseases (2012, background): “disease might be caused by a primary intestinal barrier malfunction that leads to a secondary inflammatory response and is maintained by chronically activated immune cells in the bowel [113].”
- Metagenomic biomarker discovery and explanation (2011, background): “In particular, mouse models of inflammatory bowel disease [63] facilitate a mechanistic evaluation of the contribution of the gut microbiota to the initiation and perpetuation of chronic intestinal inflammation, as occurs in human Crohn’s disease and ulcerative colitis [64].”
- Gut microbiota in health and disease. (2010, background): “Many aspects of the microbiota’s involvement in IBD have been expertly reviewed over the last few years (226, 233, 261, 262, 287, 340).”
- Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis (2008, background): “Defects in these components have been implicated in human IBD, although fundamental knowledge of underlying pathogenesis remains very poorly understood, with even the most well-established defect, CARD15 mutations, elucidating only a subset of white patients with ileal Crohn’s disease [9,10], and wi”
- Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease (2011, background): “INTRODUCTION Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is characterised by chronic intestinal inflammation, with potentially severe complications and even mortality.(1) Although the exact aetiology is unclear, it is thought to result from a combinati”
- Role of the Microbiota in Immunity and inflammation (2014, background): “Conversely, aberrant accumulation of commensal-specific T cells may lead to the development of inflammation and IBD (Sartor, 2006).”
- The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “Crohn's disease is a chronic gastrointestinal disorder with an unknown etiology characterized by an inflammatory response of the intestinal mucosa (Sartor, 2006).”
- Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum (2007, background): “…such as Mycobacterium avium subspecies paratuberculosis, Listeria, Streptococcus and Escherichia coli, (Liu et al., 1995; Shanahan and O’Mahony, 2005; Sartor, 2006; Barnich and Darfeuille-Michaud, 2007), or imbalances in the ratio of beneficial to harmful bacteria termed ‘dysbiosis’, implicated in…”