Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites

By Craig D. Kaplan, Lisa Laprade, F. Winston. Science, 2003

627 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7f86022a093bfc7df24a3d2a5d3f83e1a485a300

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Citations in the corpus

Elongation by RNA polymerase II: the short and long of it. (2004, background): “As discussed above, FACT and Spt6 have been shown experimentally to be important in maintaining chromatin structure disrupted by active transcription (Kaplan et al. 2003; Mason and Struhl 2003).”
The complex language of chromatin regulation during transcription (2007, background): “Several years ago, it was shown that transcriptional initiation can occur inside ORFs through 'cryptic' TATA boxes, and that internal initiation is detrimental to normal transcriptio”
The role of chromatin during transcription. (2007, background): “…mutations in histone chaperones known to affect elongation, such as Spt6, Spt16 (FACT), and Asf1, all lead to the generation of cryptic transcripts initiated from internal start sites within the body of yeast genes (Kaplan et al., 2003; Mason and Struhl, 2003; Schwabish and Struhl, 2004, 2006).”
Gene regulation by the act of long non-coding RNA transcription (2013, background): “TI by nucleosome repositioning may be a general mechanism in yeast, as the RNAPII elongation and chromatin organization factors responsible for SER3 silencing are also known to be involved in the suppression of transcription initiation from cryptic promoters within the body of actively transcribed g”
Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T‐cell receptor α/δ locus (2004, background): “Although polII transcription undoubtedly disrupts nucleosome structure, polII-associated nucleosome reassembly factors rapidly reconstitute nucleosomes in the wake of the elongation complex (52).”
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. (2005, background): “The FLO8 3# ORF primer set amplifies a region that contains the cryptic promoter (Kaplan et al., 2003).”
Understanding the language of Lys36 methylation at histone H3 (2012, positive): “through association of the chromodomain -containing Rpd3S subunit ESA1-associated factor 3 (Eaf3) with H3K36me3; this enforces a deacetylated chromatin state in the wake of transcribing RNAPI”
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. (2005, neutral): “The chromatin remodeler Chd1 contains a chromodomain and interacts indirectly with the PAF complex via the elongation factor Spt16/Pob3 (FACT) (Krogan et al., 2002b).”
Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription (2007, background): “In yeast, several elongation factors have been identified that are responsible for chromatin assembly after polymerase transi”