Oxyl radicals, redox-sensitive signalling cascades and antioxidants.

By M. Genestra. Cellular Signalling, 2007

629 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/7f62f3d14e86ea301cd20eba7a7f2ed47f5cbe09

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Hartwig
2. Zhushan Fu
3. Liying Wang
4. Y. Rojanasakul
5. Shuhua Xi
6. A. Gorman
7. D. Beyersmann
8. Simone Fulda

In Molecular Biology

1. C. Pham-Huy
2. Lien Ai Pham-Huy
3. M. Mouradian
4. Hua-Dong He
5. A. Hartwig
6. Zhushan Fu
7. V. Dias
8. Liying Wang

In Nutrition and Dietetics

1. A. Hartwig
2. Zhushan Fu
3. Chunyan Guo
4. J. Kong
5. Xueping Chen
6. Shuhua Xi
7. D. Beyersmann

Citations in the corpus

• Endoplasmic reticulum stress: molecular mechanism and therapeutic targets (2023, background): “Antioxidant systems in cells can significantly prevent ROS production by direct action on radical chain reactions and through detoxifying enzymes like superoxide dismutase (SOD) and catalase, which produce peroxidases.(24) The generation of ROS relies on several enzymes like nicotinamide adenine din”
• Oxidative stress in neurodegenerative diseases (2012, background): “Molecules such as hydrogen peroxide (H2O2), ozone (O3), singlet oxygen (1O2), hypochlorous acid (HOCl), nitrous acid (HNO2), peroxynitrite (ONOO ), dinitrogen trioxide (N2O3), lipid peroxide (LOOH), while not considered free radicals, can easily lead to free radical reactions in living organisms [5]”
• Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity (2013, background): “Thus, ROS response appears to be closely related to factors driving carcinogenesis [98].”
• The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “This decrease in GSH levels can result from decreased synthesis due to inhibition of glutathione reductase, or from increased levels of glutathione disulfide (GSSG) and altered GSH:GSSG ratio [89].”
• Oxidative Stress: Harms and Benefits for Human Health (2017, background): “Nonenzymatic free radical production can occur as well during mitochondrial respiration [15, 16, 19].”
• Free Radicals, Antioxidants in Disease and Health (2008, background): “Nitric oxide radical (NO•) is formed in biological tissues from the oxidation of L-arginine to citrulline by nitric oxide synthase (3-8).”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “In fact, oxidants and antioxidants not only determine cell fate, but can also modulate the mode of cell death [186, 190].”
• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “ROS activate varied signal transduction pathways such as AP1, NF- B, insulin receptor kinase, MAPKs, and Src kinases which regulate proliferation, differentiation, and apoptosis of epithelial cells (46, 102).”
• Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases (2014, background): “These non radical species are not free radicals but can easily lead to free radical reactions in living organisms [18].”
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms (2008, background): “Besides generating DNA damage directly, reactive oxygen species at low concentrations function as mitogenic signals and activate redox-sensitive transcription factors (Genestra 2007).”
• Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action (2022, methodology): “Most importantly, when the production of free radicals overwhelms the antioxidant defenses, it leads to OS, the harmful mechanism that can significantly change cell membranes and other biological structures such as lipoproteins, lipids, proteins, DNA etc. (Genestra, 2007).”
• Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles (2016, background): “Thus, ROS-NFκB mediated IL-8 expression response appears to be closely associated to factors driving cancer progression and metastasis (Genestra, 2007).”
• Oxidative stress, aging, and diseases (2018, methodology): “determine deleterious effects but also involved in the extraction of energy from organic molecules, in immune defense, and in the signaling process.(5) There are endogenous”
• Prevalence of exposure of heavy metals and their impact on health consequences (2018, background): “One of which is activation of transcription factors which are redox sensitive whereas other function involves its role as mitogenic signals.(5) Likewise, another pathway for heavy metals to cause carcinogenicity has been considered as the process of DNA repair interference.”
• The effects of heavy metals on human metabolism (2019, background): “One is the activation of redox-sensitive transcription factors, while the other functions involves its role as a mitotic signal (Genestra 2007).”