Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

By D. Beyersmann, A. Hartwig. Archives of Toxicology, 2008

1,167 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/34766b82734486f044211035e04543d49c83d06b

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In Health, Toxicology and Mutagenesis

1. L. Rink
2. R. Azevedo
3. Anita Singh
4. E. Rodriguez

In Nutrition and Dietetics

1. H. Haase
2. L. Rink
3. R. Azevedo
4. E. Rodriguez

Citations in the corpus

• Effect of cadmium, copper and zinc on plants, soil microorganisms and soil enzymes. (2012, neutral): “Plant species or even cultivars might differ from one another in the tolerance to excessive quantities of cadmium, copper and zinc and in their ability to absorb these elements (V IG et al. 2003, C IEÆKO et al. 2001, S EKLER et al. 2007, B EYERSMANN , H ARTWIG 2008, Z ALEWSKA 2012, N ADGÓRSKA -”
• A new look at biomedical Ti-based shape memory alloys. (2012, background): “In addition to this, concerns over its genotoxicity [13], carcinogenicity [14,15] and potential mutagenicity [16,17] abound.”
• Reduction of heavy metal load in food chain: technology assessment (2011, background): “2009). In addition, several metals have been classified as carcinogenic and mutagenic ( Beyersmann and Hartwig 2008 ).”
• Prevalence of exposure of heavy metals and their impact on health consequences (2018, background): “Living systems do not degrade heavy metals which ultimately leads to their accumulation up to harmful levels.(4) Various carcinogenic pathways induced by heavy metal exposure have been established by researchers.”
• The Essential Toxin: Impact of Zinc on Human Health (2010, background): “other metals such as cadmium, cobalt, nickel, and arsenic [71].”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “One of the major mechanisms of metal carcinogenicity is the ability of transition metal ions to induce oxidative stress [35].”
• Chromium toxicity and tolerance in plants (2013, background): “Cr(III) has been observed to react directly with DNA, forming DNA adducts, thereby suggesting DNA damage (Beyersmann and Hartwig 2008).”
• Heavy Metals Toxicity and the Environment (2012, background): “Metal ions have been found to interact with cell components such as DNA and nuclear proteins, causing DNA damage and conformational changes that may lead to cell-cycle modulation, carcinogenesis, or apoptosis [20–22].”
• Phytotoxicity of Mercury in Plants: A Review (2012, background): “The toxicity of metals and their compounds largely depends on their bioavailability, that is, the mechanisms of uptake through cell membranes, intracellular distribution, and binding to cellular macromolecules [18].”