Characterization of Mammalian Selenoproteomes

By G. Kryukov, S. Castellano, S. Novoselov, A. Lobanov, Omid Zehtab, Roderic Guigó, Vadim N. Gladyshev. Science, 2003

2,243 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Surgery

View Paper: https://www.semanticscholar.org/paper/7f17210aac00d6b1bc947e3bfadf715d46d9654d

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Citations in the corpus

Ferroptosis: mechanisms and links with diseases (2021, background): “The Sec-tRNA must first be activated by the addition of an isopentenyl lipid group, a product of the mevalonate (MVA) pathway.(109,110) This may explain how disruption of the MVA pathway by statins leads to reduced GPx4 expression and increased ferroptosis in certain cells.”
Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, neutral): “Incorporation of Sec is limited to * 25 proteins and their re-lated isoforms in mammalian species (206) in a process that involves the recognition of a UGA (opal) stop codon as a site for Sec incorporation rather than termination of translation.”
Identification and Classification of Conserved RNA Secondary Structures in the Human Genome (2006, background): “In eukaryotes the SECIS has previously only been found in the 39UTR of selenoprotein transcripts [38,44,45], but in prokaryotes it is found in coding regions downstream of the UGA codon [38,46].”
Hydrogen Peroxide: A Signaling Messenger (2006, neutral): “Thus clearly one advantage of maintaining intracellular H O levels below 0.7 µ M is preventing the inadvertent oxidative inhibition of the numerous thiolate-dependent enzymes in the cell.”
Effects of vitamin E and selenium on the performance and immune status of ewes and lambs (2004, background): “Up to 25 selenoprotein genes have been identified in completely sequenced mammalian genomes consistent with earlier 75Se labelling studies used to identify the selenoproteins (Kryukov et al. 2003).”
Selenium and selenocysteine: roles in cancer, health and development (2014, background): “Approximately half of these genes code for proteins with known functions [22] (Fig.”
Selenium in the Environment, Metabolism and Involvement in Body Functions (2013, background): “Selenocysteine is present in selenoprotein once per subunit except Selenoprotein-P (SelP) wich contain 10 (humain, rat) or 12 (bovine) secys in its polypeptides chain [37,38].”
Selenium, Selenoproteins, and Immunity (2018, background): “Selenoprotein V SELENOV, SELV Testes-specific expression [21].”
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases (2016, background): “However, because the genetic code of selenocysteine is UGA, which is identical to the termination codon, a specific transporter is required for the insertion of selenocysteine into GPx4 [56].”
Ferroptosis: Death by Lipid Peroxidation. (2016, background): “The selenocysteine-tRNA (tRNA(Sec)), is one of the key components of the machinery and controls the biosynthesis of all 25 selenoproteins present in humans [33].”
Homeostasis and toxicology of essential metals (2012, methodology): “…total number of selenoproteins among taxa, with no functional selenoproteins definitively found in yeast or terrestrial plants, only one in the nematode Caenorhabditis elegans, three in Escherichia coli and Drosophila melanogaster, and about 23–25 in mammals including humans (Kryukov et al., 2003).”
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “It has been found to play an important role in at least 25 human selenoproteins by being part of the primary amino acid sequence as selenocysteine (SeCys) [210,211].”
First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid (2018, background): “This invariably implies that these forms of GPx may not be able to effectively scavenge H2O2, a feature which is characteristic of the selenium-dependent glutathione peroxidases.(52) The clinical importance of GPx has been underlined by a number of studies.”