Selenium and selenocysteine: roles in cancer, health and development

By D. Hatfield, P. Tsuji, B. Carlson, Vadim N. Gladyshev. TIBS -Trends in Biochemical Sciences. Regular ed, 2014

642 citations recorded by the source corpus.

The many biological and biomedical effects of selenium are relatively unknown outside the selenium field. This fascinating element, initially described as a toxin, was subsequently shown to be essential for health and development. By the mid 1990s, selenium emerged as one of the most promising cancer chemopreventive agents, but subsequent human clinical trials yielded contradictory results. However, basic research on selenium continued to move at a rapid pace elucidating its many roles in health, development, and cancer prevention and promotion. Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/631606a30b7feb54871a00ee3e79e8c1401a8448

How researchers see this paper

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In Health, Toxicology and Mutagenesis

1. S. Clemens
2. Elias S. J. Arnér
3. Meetu Gupta
4. J. Ma
5. Shikha Gupta

In Nutrition and Dietetics

1. S. Clemens
2. Elias S. J. Arnér
3. Meetu Gupta
4. M. Conrad
5. F. Ursini
6. Shikha Gupta

Citations in the corpus

• Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. (2017, positive): “Sec incorporation, at the opal codon UGA, is a highly complex and energetically costly process (Hatfield et al., 2014).”
• An Overview of Selenium Uptake, Metabolism, and Toxicity in Plants (2017, background): “Although, Se performs in variety of functions, its antioxidant and anticancerous properties are of primary concern for mankind (Reid et al., 2008; Wallace et al., 2009; Hatfield et al., 2014).”
• Toxic Heavy Metal and Metalloid Accumulation in Crop Plants and Foods. (2016, background): “Plant-derived food represents the main dietary source of Se, and insufficient Se intake is associated with several human diseases (43).”
• Ferroptosis: mechanisms and links with diseases (2021, background): “Selenium has been involved in many biological processes such as cancer prevention and promotion, protecting against cardiovascular diseases, and treating certain muscle disorders.(106) The GPx4 mRNA contains a selenocysteine insertion sequence element in the 3’ untranslated region that encodes an ac”
• Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. (2016, background): “SEPW1(Selenoprotein W) is one of most important member of selenoprotein W-like family [27,28].”