Ferroptosis: Death by Lipid Peroxidation.

By W. Yang, Brent R. Stockwell. Trends in Cell Biology, 2016

2,709 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/e9c3b8a95cc204a2c838edd196ef9471c4551133

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In Cancer Research

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In Pulmonary and Respiratory Medicine

Citations in the corpus

Role of Mitochondria in Ferroptosis (2018, background): “Ferroptosis, an iron-dependent form of regulated necrosis, has emerged as a new cell death modality highly relevant to disease (Angeli et al., 2017; Gao and Jiang, 2017; Stockwell et al., 2017; Yang and Stockwell, 2016).”
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death (2017, positive): “7,8 − 11 The induction of ferroptosis o ﬀ ers a new strategy for killing cancer cells, and disruption of the regulatory framework that keeps ferroptosis in check may contribute to the pathogenesis of degenerative diseases in which LOOH accumulation has been implicated.”
The Development of the Concept of Ferroptosis (2018, positive): “[118], supported by the previous identification of lipophilic antioxidants as suppressors of ferroptotic death induced by erastin and other compounds [111].”
Metallothionein-1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis (2016, background): “Ferroptosis is characterized by the accumulation of lipid peroxidation products that require abundant and accessible cellular iron((10,11)); thus, we further investigated whether MT-1G is involved in the regulation of lipid peroxidation and iron metabolism leading to sorafenib resistance.”
Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis (2016, background): “Ferroptosis is a recently characterized form of iron-dependent, nonapoptotic cell death with distinct morphological and mechanistic characteristics [26].”
CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy (2019, methodology): “To study whether ferroptosis involves in the anti-tumor activity of cancer immunotherapy, ID8 ovarian tumor bearing mice were treated with the programmed death-ligand 1 (PD-L1) blockade, and the lipid peroxidation, as a functional marker for ferroptosis 5,11 , was assessed in single cells.”
FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations (2020, background): “The text is truncated if the cell is not wide enough to display all of the text with an ellipsis button displayed at the end (inset (1) in Figure 3).”
NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases (2021, background): “As the driving force of ferroptosis, a high level of lipid peroxidation can disrupt cellular function [56].”
Inhibition of neuronal ferroptosis protects hemorrhagic brain. (2017, background): “Recently, ferroptosis, an iron-dependent form of nonapoptotic cell death, was identified in cancer cells and mouse embryonic development (24–26).”
Glutathione metabolism in cancer progression and treatment resistance (2018, background): “Ferroptosis is also triggered by the loss of GSH peroxidase 4 (GPX4), which leads to the accumulation of lipid peroxides (Yang and Stockwell, 2016; Yu and Long, 2016).”
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “The process of ferroptosis involves the production of soluble and lipid ROS via enzymatic reactions mediating transition metal iron (Fe) [52].”
Lipid peroxidation in cell death (2017, background): “Recent work has also identified lipid peroxidation as the primary driver of ferroptosis, a type of regulated necrotic cell death [43].”