Superoxide dismutase as a target for the selective killing of cancer cells

By Peng Huang, Li Feng, E. Oldham, M. Keating, W. Plunkett. Nature, 2000

869 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/7f04954e3ea2149d9ba23bd75ac11561e393b4c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. L. Galluzzi
2. Guido Kroemer
3. Simone Fulda
4. Yongqiang Chen
5. S. Gibson
6. D. Trachootham
7. Peng Huang
8. Y. Bae

Citations in the corpus

• Multiple myeloma: evolving genetic events and host interactions (2002, neutral): “130 )) and the anti-angiogenic agent 2-methoxyestradio”
• Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (2009, background): “Examples of SOD inhibitors include certain oestrogen derivatives such as 2-methoxyestradiol (2-ME”
• Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, background): “It was initially reported to inhibit SOD2 and copper, zincsuperoxide dismutase (SOD1), thereby increasing ROS levels.(35) However, this conclusion was challenged.”
• Targeting mitochondria for cancer therapy (2010, background): “Some oestrogen derivatives such as 2-methoxyoestradiol selectively kill human leukaemia cells (but not normal lymphocytes) by inhibiting SOD and hence causing superoxide accumulatio”
• Mitochondrial defects in cancer (2002, background): “This biochemical change provides an unique opportunity to selectively kill this population of cancer cells by using agents that inhibit free radical elimination and cause further ROS accumulation, leading to lethal damage in the cancer cells [92].”
• Redox Regulation of Cell Survival (2008, neutral): “Such ROSmediated therapeutic strategies have been tested in various experimental systems with promising results (128).”
• Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “As cancer cells are sensitive to oxidative stress, modulation of SOD has been exploited as a mechanism to selectively kill cancer cells (P. Huang et al. 2000).”
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “2-Methoxyestradiol is another known inhibitor of SOD that has the potential to increase superoxide radical levels (128).”
• Regulation of reactive oxygen species generation in cell signaling (2011, background): “5-FU, arsenic trioxide, cisplatin, paclitaxel, bleomycin, and adriamycin have also been reported to trigger ROS generation (Adler et al., 1999; Huang et al., 2000; Hwang et al., 2001; Marcillat et al., 1989; Miyajima et al., 1997; Pelicano et al., 2003; 2004; Tan et al., 1998).”
• Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, neutral): “ME, a promising antitumor agent currently in phase I and II clinical trials, enhances ROS formation by inhibiting complex I of the mETC (40) and mitochondrial SOD (45).”