Targeting mitochondria for cancer therapy

By Simone Fulda, L. Galluzzi, Guido Kroemer. Nature reviews. Drug discovery, 2010

1,587 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ccf7bd587e501380b0c4d20b5e63ba7457c831ff

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Citations in the corpus

Apoptosis and Molecular Targeting Therapy in Cancer (2014, background): “, G3139 [103]), various drugs molecules that target Bcl-2 and Mcl1 have been tested for their abilities to induce apoptosis in cancer cells [104].”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “HMGB1 is transferred from the nucleus to the cytoplasm and promotes the formation of the Beclin1–PI3KC3 complex by activating the mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling pathway [99].”
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “The mechanism by which the cell dies appears to be dependent on the type of stress, intensity and time frame of exposure (Fulda et al. 2010).”
Anti-apoptosis and cell survival: a review. (2011, background): “Anti-apoptotic phenotypes of tumor cells are developed in response to the stressful microenvironments, that include limitations on nutrients and oxygen availability, in which they develop [46,158,198].”
Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “The intrinsic (mitochondrial) pathway of apoptosis is mediated by the release of apoptogenic proteins, including cytochrome c and second mitochondria-derived activator of caspase (SMAC; also known as DIABLO), from the mitochondrial intermembrane space into the cytoso”
Nanomedicine in cancer therapy (2023, background): “391 391 – 393 As such, mitochondria have attracted growing attention as promising targets for cancer therapy.”
Mitochondrial metabolism and cancer (2017, background): “As a consequence, considerable efforts were focused on the development of molecules that would target mitochondria as a strategy for chemo- or radiosensitization [20], and some of these agents are nowadays used in the clinics (e.”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “This phenomenon, which is known as mitochondrial permeability transition (MPT), results in immediate dissipation of the mitochondrial membrane potential and osmotic swelling of the mitochondrial matrix [2].”
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. (2015, background): “This can be attained with cytotoxic drugs that target rapidly proliferating cells, especially when these cells, like cancer cells, are particularly vulnerable because of aberrations in the mechanisms that control adaptive stress responses and cell death (Fulda et al., 2010; Solimini et al., 2007).”
All-atom 3D structure prediction of transmembrane β-barrel proteins from sequences (2015, background): “These roles include outer-membrane protein biogenesis (3, 4), antibiotic resistance (5), vaccine design, translocation of virulence factors, and the design of cancer therapeutics (6).”
Ageing as a risk factor for disease. (2012, background): “Cancer In cancer cells, mtDNA can be highlymutated, and numerous polymorphisms and mtDNA mutations have been linked to increased cancer susceptibility [72], suggesting that mtDNA alterations, like nuclear genomic alterations, play an important role in cancer development.”