Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses.

By S. O'Mahony, Julian R. Marchesi, P. Scully, Caroline E. Codling, Anne-Marie Ceolho, E. Quigley, J. Cryan, Ted G. Dinan. Biological Psychiatry, 2009

1,052 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Gastroenterology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7e8c63e263b18c42068858e7aa566255cfcb86d0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. J. Cryan
2. Ted G. Dinan
3. Yan Wang
4. Bruno Bonaz
5. L. Kasper
6. G. Clarke

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. C. Stanton
6. R. Stilling
7. Yan Wang
8. L. Kasper

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. P. Kennedy
6. R. Stilling
7. Yan Wang
8. L. Kasper

Citations in the corpus

• Gut microbiome-host interactions in health and disease (2011, background): “More novel approaches that incorporate parasites that interact with the gut microbiome have also been suggested, such as the use of helminths in IBD [90].”
• Psychobiotics: a novel class of psychotropic. (2013, background): “However, it has been established that early life stress, which is a risk factor for major depression in adulthood, induces changes in the microbiota (36,37).”
• The role of microbiome in central nervous system disorders (2013, positive): “O’Mahony et al. (2009) illustrated that an early life stress (maternal separation) increased systemic corticosterone level and immune responses and altered fecal microbiota in rats.”
• Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. (2017, neutral): “Alterations in the hypothalamic-pituitary-adrenal axis have been linked to the development of mood disorders and have been shown to affect the composition of the microbiota in rodents (37).”
• The Microbiome-Gut-Brain Axis in Health and Disease. (2017, background): “Prior studies in maternally separated rats demonstrated an altered behavioural phenotype when these animals reached maturity and also decreased diversity in the microbiota 20 .”
• The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis (2018, background): “Stress, either interoceptive or exteroceptive, is involved in the pathophysiology of IBS and IBD and can modify the gut microbiota (O’Mahony et al., 2009; Konturek et al., 2011; Bonaz, 2013; Barbara et al., 2014).”
• Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve (2011, background): “Alterations in the HPA axis have been linked to the development of mood disorders and have been shown to affect the composition of themicrobiota in rodents (26).”
• Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries (2014, methodology): “REVIEW ARTICLE published: 02 June 2014 doi: 10.3389/fmicb.2014.00207 Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries”