TLR signaling.

By Taro Kawai, Shizuo Akira. Current Topics in Microbiology and Immunology, 2006

2,545 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7e89d7ce8aceee83e96fff5ad4256dd78eb180d8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Kui Li
2. Sandra N. Lester
3. Jerrold M. Olefsky
4. V. Dixit
5. L. Liaudet
6. N. Mizushima
7. A. Takaoka
8. H. Yanai

In Immunology

1. H. Yanai
2. N. Rosenblatt-Velin
3. Kui Li
4. M. Lamkanfi
5. Sandra N. Lester
6. Jerrold M. Olefsky
7. Jing-Huan Wang
8. V. Dixit

In Molecular Biology

1. P. Calder
2. M. Lamkanfi
3. V. Dixit
4. N. Rosenblatt-Velin
5. Kui Li
6. Sandra N. Lester
7. Jerrold M. Olefsky
8. Jing-Huan Wang

Citations in the corpus

• Inflammasomes and their roles in health and disease. (2012, background): “PRRs enable innate immune cells to instantly detect and respond to the presence of danger- and pathogen-associated molecular patterns (DAMPs and PAMPs, respectively) (Kanneganti et al. 2007).”
• GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. (2010, positive): “Since the TNF-a and TLR signaling cascades converge downstream of GPR120 activation, these results indicate that the site of GPR120-induced inhibition is either at, or upstream, of JNK/ IKKb.”
• The role of oxidative stress during inflammatory processes (2013, background): “…by C-terminal leucine-rich repeat domain for ligand sensing, a central nucleotide-binding and oligomerization domain for activation, and an N-terminal domain for downstream signaling whose structure defines different subfamilies of NLRs (NLRA, NLRB, NLRC, NLRP, and NLRX) (Kersse et al.,…”
• TAM receptors are pleiotropic inhibitors of the innate immune response. (2007, background): “TRAF6 was immunoprecipitated and analyzed by immunoblotting with ubiquitin (top blot) and TRAF6 (bottom blot) antibodies.”
• Autophagy: process and function. (2007, background): “Among these, TLR7 recognizes viral ssRNA in endosomes and triggers immune responses, such as induction of inflammatory cytokines (Kawai and Akira 2006).”
• Toll-like receptors in antiviral innate immunity (2013, background): “Their signal transduction pathways also vary, being either myeloid differentiation primary response 88 (MyD88) dependent or TIR-domaincontaining adaptor inducing interferon (IFN)-β (TRIF, also known as TICAM1) dependent based on adaptor usage [16,17].”
• Interferon signalling network in innate defence (2006, background): “…the activation of pattern recognition receptors (PRRs) including TLRs (Takeda et al ., 2003; Akira and Takeda, 2004; Takeda and Akira, 2005; Kawai and Akira, 2006) and retinoic acidinducible gene-I (RIG-I) and melanoma differentiationassociated gene 5 (Mda5) (Rothenfusser et al ., 2005; Yoneyama…”
• The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis (2014, background): “TAK1 affects the phosphorylation of the IκB kinase complex (IKK), thereby activating the transcription factor NF-κB [25].”