TAM receptors are pleiotropic inhibitors of the innate immune response.

By C. Rothlin, Sourav Ghosh, E. Zúñiga, M. Oldstone, G. Lemke. Cell, 2007

1,024 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/c4814c2014afb561e30270f369141d18a90b5d3b

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In Immunology

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Citations in the corpus

• Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, neutral): “It is well known that TAM family receptors/ligands are expressed in macrophages 15 .”
• Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, background): “For example, IL-4 and IFN-γ, the latter in concert with TLR stimulation, upregulate SOCS1 (31) and SOCS3 (32), which in turn, inhibit the action of STAT1 and STAT3, respectively.”
• Origin and physiological roles of inflammation (2008, background): “This is exemplified by the recently described anti-inflammatory pathway controlled by the TAM family of receptor tyrosine kinase”
• Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer (2016, background): “Unlike Mertk that is constitutively expressed on macrophages and DCs, under basal conditions the expression of Axl in DCs is low, but is significantly upregulated as a consequence of TLR engagement to resolve and break inflammation in anticipation of the end of an inflammatory cycle.52 At a mechanis”
• Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, positive): “Interestingly, TAM receptors have recently been linked to the suppression of TLR signaling, revealing one mechanism by which apoptotic cell clearance and immune tolerance are coupled (Lemke and Rothlin, 2008; Rothlin et al., 2007).”
• The role of defective clearance of apoptotic cells in systemic autoimmunity (2010, background): “In parallel, these receptors inhibit responses induced by Toll-like receptors (TLRs) and cytokines in DCs and macrophages, including those leading to the production of type I interferons (type I IFNs)”
• Signaling in innate immunity and inflammation. (2012, background): “TAM (Tyro3, Axl, and Mer) receptor tyrosine kinases are further examples of receptor systems that negatively regulate TLR signaling (Rothlin et al. 2007).”