GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.

By Da Young Oh, Saswata Talukdar, E. Bae, Takeshi Imamura, H. Morinaga, WuQiang Fan, Pingping Li, Wendell J. Lu, S. Watkins, Jerrold M. Olefsky. Cell, 2010

2,155 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/03be91be1533de25ff2fdd9c29fca52b280db839

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In Endocrinology, Diabetes and Metabolism

In Molecular Biology

Citations in the corpus

Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects (2014, positive): “Insulin-sensitizing and anti-inflammatory effects and GLP-1 secretion are also observed with u-3 fatty acids (Hirasawa et al., 2005; Oh et al., 2010).”
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, positive): “The interaction between LPS and TLR4 induces the synthesis of pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, IL-8, and IL-12, which, in turn, work as endogenous inflammatory mediators by interacting with receptors found in different target cells.”
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018, positive): “The anti-inflammatory effects of omega-3 fatty acids seems to be mediated by binding to the G-protein–coupled receptor 120 and inhibition of NLRP3 inflammasome activity (53,54).”
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013, positive): “…regulation is still unclear. u-3 FAs have been shown to inhibit the production of proinflammatory cytokines, including IL-1b (Endres et al., 1989; Oh et al., 2010; Robinson et al., 1996), and this prompted us to investigate whether u-3 FAs exert their anti-inflammatory activity via inhibition of…”
Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021 (2021, neutral): “GPR120 is a plasma membrane G protein coupled receptor (also 477 called free fatty acid receptor 4) that is able to bind long-chain fatty acids, especially DHA 478 [151].”
Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “Many metabolites, for example, fatty acids and ketones , can be monitored both directly by GPCRs (Briscoe et al., 2003; Oh et al., 2010) and through their flow into Controllers where they are metabolized.”
Macrophage-mediated inflammation in metabolic disease (2011, neutral): “Lastly, loss of GPR120, a G protein-coupled receptor that mediates the anti-inflammatory actions of omega-3 unsaturated fatty acids, worsens adipose tissue inflammation and insulin resistanc”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, positive): “The GPR120db arrestin-2 complex then undergoes endocytosis and the internalized b arrestin-2 binds to TAB1, ‘‘stealing’’ it from the TAK1 complex, causing TAK1 inactivation with inhibition of subsequent downstream proinflammatory signaling.”
β-arrestin-mediated receptor trafficking and signal transduction (2011, positive): “This blockade of inflammatory cytokine receptor signalling promotes the return of antiinflammatory macrophages to adipose tissue and restores insulin sensitivity in obese mice [107].”
The Microbiome in Infectious Disease and Inflammation (2012, positive): “By preventing macrophageinduced chronic, low-grade tissue inflammation, GPR120 mediates anti-inflammatory and insulin-sensitizing effects in vivo (119).”