Role for Rab7 in maturation of late autophagic vacuoles

By S. Jäger, C. Bucci, I. Tanida, T. Ueno, E. Kominami, P. Saftig, E. Eskelinen. Journal of Cell Science, 2004

943 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/7e744273c22fc79b0d6f2e5805a8228ad06a477a

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Citations in the corpus

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes (2006, background): “AVis are not Rab7-positive and do not contain degradative enzymes, whereas AVds have acquired both Rab7 and degradative enzymes (Gutierrez et al., 2004; Jager et al., 2004).”
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009, background): “Interestingly, analysis of LAMP-deficient cells revealed that RAB7 recruitment to autophagosomes and their fusion with lysosomes was severely retarde”
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation (2012, neutral): “Additional Rabs displayed a range of effects on autophagic killing of BCG, including those Rabs previously implicated in autophagy, e.g., Rab7, Rab32, and Rab33b (Hirota and Tanaka, 2009; Itoh et al., 2011; Jäger et al., 2004), with the notable exception of Rab24 (Olkkonen et al., 1993).”
Regulation Mechanisms and Signaling Pathways of Autophagy (2009, background): “In mammalian cells, the fusion event requires the lysosomal membrane protein LAMP-2 and the small GTPase Rab7 (51,147), although the mechanism is less characterized.”
Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins (2015, positive): “The lipidated, membrane-associated LC3-II is associated with both outer and inner autophagosomal membranes and remains on autophagosomes during formation, completion and fusion with the lysosome 39,40 .”
Autophagy as a target for anticancer therapy (2011, background): “Finally, a retrieval pathway is required for the disassembly of Atg protein complexes from matured autophagosomes (mediated by Atg2, Atg9, and Atg18)”
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation (2007, methodology): “LC3 conversion from I to II was examined by immunoblot analysis using anti-LC3.(20,23,51) Cells were treated with Hank’s Balanced Salt Solution (HBSS) or incubated with Bre (2 mg/ml), Tm (2 mg/ml), Thap (2mM), Rap (10 mg/ml) (Sigma), and lysed with phosphate buffered saline (PBS) containing 1% Trito”
Autophagy: molecular machinery for self-eating (2005, background): “is targeted to the autophagosome membrane and is involved in a late step, fusion with the lysosome, to allow maturation.(88,89) In contrast to mammalian Rab GTPase, it has not”
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport (2010, background): “In mammals, Rab7, the core class C Vpstethering complex and UVRAG are important for fusion of autophagosomes with lysosomes (Gutierrez et al., 2004; Jäger et al., 2004; Liang et al., 2008).”
Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “Rab GTPases likely play a role in vesicle maturation and fusion with lysosomes (27).”
LAMP proteins are required for fusion of lysosomes with phagosomes (2007, background): “Rab7 recruitment and activation were shown to be necessary for completion of phagosome maturation (Harrison et al, 2003; Jager et al, 2004).”
Lysosomes: fusion and function (2007, background): “In mammalian cells, RAB7 has been implicated in the fusion of autophagosomes with lysosome”
Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “As described above, autophagosome–lysosome fusion is impaired in LAMP-double deficient cells [32].”
ER stress: Autophagy induction, inhibition and selection (2015, background): “Similarly, autophagosomal transport and fusion is substantially mediated by the small GTPase RAB7A/RAB7 and its association with FYCO1 (FYVE and coiled-coil domain containing 1) and lysosomal membrane proteins LAMP1/2 accelerate the fusion machinery.(88,89) ATG9, an integral membrane protein, is als”