LAMP proteins are required for fusion of lysosomes with phagosomes

By K. Huynh, E. Eskelinen, Cameron C Scott, A. Malevanets, P. Saftig, S. Grinstein. EMBO Journal, 2007

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Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009, background): “The significance of the intracellular localization of LAMPs is further exemplified by the observation that in LAMP-deficient cells the distribution of lysosomes is more dispersed and peripheral, suggesting that lysosome migration towards the microtubule organization centre is delaye”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “involved in the fusion of late endosomes and autophagosomes or phagosomes.(1118,1119) LAMP2C, one of the LAMP2 isoforms, can also function as an RNA/DNA receptor in RNautophagy”
Lysosomes: fusion and function (2007, background): “Cells that are depleted of lysosomal-associated membrane protein-1 (LAMP1) and LAMP2 show abnormal phagosome maturatio”
Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “Thematuration block caused by LAMP deficiency is at least partially due to the inability of autophagosomes and phagosomes to undergo dynein/dynactinmediated centripetal movement along microtubules towards lysosomes [158].”