The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

By Xaralabos Varelas, Payman Samavarchi-Tehrani, M. Narimatsu, Alexander Weiss, Katie Cockburn, B. Larsen, Janet Rossant, Jeffrey L. Wrana. Developmental Cell, 2010

757 citations recorded by the source corpus.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/7e64f81d484d8de153e256711af5d60555091cb3

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In Cell Biology

1. K. Guan
2. S. Piccolo
3. Fa-Xing Yu
4. Bin Zhao
5. M. Cordenonsi
6. S. Dupont
7. Xaralabos Varelas
8. Duojia Pan

Citations in the corpus

• Hippo pathway regulation by cell morphology and stress fibers (2011, background): “The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.”
• The Hippo pathway: regulators and regulations. (2013, background): “In keratinocytes and mammary epithelial cells, calcium depletion led to disruption of cell junctions and YAP/TAZ nuclear enrichment (Varelas et al. 2010; Schlegelmilch et al. 2011).”
• The Hippo Signaling Pathway in Development and Disease (2019, background): “Although mammals lack a clear Ex ortholog, the involvement of Crb in Hippo signaling appears to be conserved as CRB3 acts with angiomotin (AMOT)-like proteins to promote Hippo signaling (Varelas et al., 2010).”
• The Hippo signalling pathway and its implications in human health and diseases (2022, background): “68 A recent study revealed that Kirre-like Nephrin Family Adhesion Molecule 1 (KIRREL1), a cell adhesion molecule, acts as a feedback regulator of the Hippo pathway in mammalian cells.”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “Depletion of Crumbs complex components, including Pals1 and the Crumbs family member Crb3, in polarized epithelial cells was found to increase nuclear TAZ/YAP localization (Varelas et al., 2010b).”
• The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal (2011, neutral): “Recently, YAP/TAZ and angiomotin (AMOT) family proteins were shown to interac”
• Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. (2012, background): “Further studies demonstrated that cell–cell junctional proteins such as the angiomotin protein complex and a-catenin inhibit YAP (Nishioka et al. 2009; Varelas et al. 2010; Chan et al. 2011; Kim et al. 2011; Schlegelmilch et al. 2011; Silvis et al. 2011; Wang et al. 2011; Zhao et al. 2011).”
• The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “In agreement with the previously proposed properties imposed on cells upon undergoing the EMT (Vega et al. 2004), the invasive cancer cells have an attenuated proliferation rate and are resistant to cell death in addition to expressing EMT markers (Roussos et al. 2010).”
• The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “Cytoplasmic YAP/TAZ participate in Smad2/3 cytoplasmic retention, even overruling the effects of high levels of TGF- ligands (207, 208).”