INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE
By Christopher K. Glass, Jerrold M. Olefsky. Cell Metabolism, 2012
893 citations recorded by the source corpus.
Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies indicate that many other lipid species act to positively and negatively regulate inflammatory responses. Conversely inflammatory signaling can significantly alter lipid metabolism in the liver, adipose tissue, skeletal muscle and macrophage in the context of infection, diabetes and atherosclerosis. Here, we review recent findings related to this interconnected network from the perspective of immunity and metabolic disease.
Subfields: Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/12c58c1fae1c4a265877c3faf5797a507ebfbedf
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In Epidemiology
In Physiology
- Satchidananda Panda
- Dirk Gevers
- Amir Zarrinpar
- A. Chaix
- Thomas Breslin
- Linda Partridge
- Luigi Fontana
- W. Sivitz
Citations in the corpus
- The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids (2015, background): “with concomitant effects on plasma lipids.(11) Gut microbiota have also been linked with lipid metabolism through their role in bile acid metabolism.”
- Mechanisms of Oxidative Stress in Metabolic Syndrome (2023, background): “lipid metabolism, hepatic lipogenesis, insulin signaling, and oxidative stress [43,49,69].”
- Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “Subsequent studies in animals and humans confirmed that obesity increases ATM numbers [5,9,49].”
- Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges (2014, background): “In the DIO model, the accumulation of fat in adipose tissue has been associated with higher inflammation (Glass and Olefsky, 2012).”
- Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “, 2014), inflammatory mediators (Brestoff and Artis, 2015; Glass and Olefsky, 2012; Mathis, 2013), and miRNAcontaining EVs.”