A ceramide-centric view of insulin resistance.

By J. Chavez, S. Summers. Cell Metabolism, 2012

597 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5fc632268d77c2c7a703bab00f68a00b97b33111

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Citations in the corpus

Cardiac Metabolism in Heart Failure - Implications beyond ATP production (2013, unknown): “Fatty acyl-CoA, particularly palmitoyl-CoA, can be used for de novo synthesis of ceramides, which has pleiotropic effects on cellular function.(13,14) Incomplete FA oxidation, particularly in skeletal muscle, may result in release of acylcarnitines from mitochondria into the cytosol and subsequently”
Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “AKT is fully activated by further mTORC2 phosphorylation and participates in several downstream pathways that regulate multiple metabolic processes including glycogen synthesis, gluconeogenesis, glycolysis and lipid synthesis.”
Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes (2014, background): “Ceramides accumulate in peripheral tissues of obese subjects.(92) Inhibition of sphingomyelin synthesis with reduced levels of ceramides prevents and improves IR in animal models of diet-induced obesity.”
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments (2023, background): “Likewise, elevated levels of ceramides of a certain chain length and saturation of fatty acids, which belong to sphingolipids, are reported to impair insulin sensitivity through reduced adiponectin and increased inflammation caused by insulin resistance initially (63, 64).”
Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “More recently, an alternative model of increased ceramide levels has also been show to associate with insulin resistance (Chavez and Summers, 2012).”
Insulin Resistance: From Mechanisms to Therapeutic Strategies (2021, background): “Ceramide Ceramide is a sphingolipid and an essential bioactive lipid produced from an intracellular fatty acid and sphingosine and is believed to mediate lipid-induced insulin resistance [125].”