Gastric Cancer Originating from Bone Marrow-Derived Cells

By J. Houghton, C. Stoicov, S. Nomura, A. Rogers, J. Carlson, Hanchen Li, Xun Cai, J. Fox, J. Goldenring, Timothy C. Wang. Science, 2004

1,219 citations recorded by the source corpus.

Subfields: Biotechnology, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/7c372effcf971e1238794bda5e7993da2287156e

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In Biotechnology

1. M. Karin
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In Genetics

1. W. Fibbe
2. Maria Ester Bernardo
3. D. Prockop
4. M. Karin
5. M. Kay
6. Benjamin Tycko
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In Oncology

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6. M. Kay
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Citations in the corpus

• A tumorigenic subpopulation with stem cell properties in melanomas. (2005, background): “Stem cells were recruited into gastric glands, differentiated into gastric epithelial cells, and developed into intraepithelial cancer (47).”
• Sarcoma Derived from Cultured Mesenchymal Stem Cells (2007, background): “Autologous MSCs may perhaps become tumorigenic [34, 35] and have been implicated in childhood leukemia [36], epithelial cancers [ 37 ], and osteogenic sarcoma [33, 38].”
• Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011, positive): “BM-derived cells (BMDCs) are often recruited to carcinogenic sites by cytokines such as IL-1b (Houghton et al., 2004; Tu et al., 2008), and indeed, CAFs promote further cell recruitment through secretion of chemokines such as SDF-1 (Orimo et al., 2005).”
• Inflammation, a Key Event in Cancer Development (2006, background): “A recent study added further details into the above model and proposed a new paradigm that might be applied to all epithelial cancers (40).”
• Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma (2006, background): “In fact, some studies suggest that MSCs may represent a precursor to tumorigenic cells (27, 28).”
• Mesenchymal stem cells reside in virtually all post-natal organs and tissues (2006, background): “, 2005), and have a tendency to acquire tissuespecific characteristics when co-cultured with specialized cell types or exposed to tissue extracts in vitro (Houghton et al., 2004; Choi et al., 2005; Lange et al., 2005).”
• Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report (2012, neutral): “179”
• Helicobacter pylori: gastric cancer and beyond (2010, background): “felis , have demonstrated that bone marrow-derived cells (BMDCs) home to and engraft in sites of chronic gastric inflammation — particularly within foci in which tissue injury induces excessive apoptosis and overwhelms the population of endogenous tissue stem cell”
• Microbiome and Malignancy (2011, background): “pylori-induced gastric inflammation recruits stem cells from the bone marrow, which may also participate in tumorigenesis (Houghton et al., 2004).”
• Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. (2009, background): “Thus, Houghton and colleagues (20) showed MSC to home from their bone marrow residence, progressing into gastric carcinomas in response to Helicobacter felis infection in mice.”
• Tumor microenvironment: The role of the tumor stroma in cancer (2007, background): “Expression is upregulated in inflamed tissues [Houghton et al., 2004], in wounds and in cancer, where it acts to attract cells expressing the receptor, CXCR4.”
• Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “The origin of human gastric CSCs has yet to be elucidated, but we have previously reported that data obtained from a mouse model of Helicobacter-induced gastric cancer have implicated bone marrow-derived cells as a potential candidate source [56,57].”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “Recent work on a mouse model of gastric cancer suggests that repeated tissue injury caused by bacterial infections (in this case caused by a relative of H. pylori—H. felis) is associated with an aberrant regenerative response that may account for this type of cancer as well (Houghton et al., 2004).”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, neutral): “can originate from bone marrow-derived sources (140).”