Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

By Lydia E. Wroblewski, R. Peek, Keith T. Wilson. Clinical Microbiology Reviews, 2010

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Management and Prevention Strategies for Non-communicable Diseases (NCDs) and Their Risk Factors (2020, background): “Helicobacter pylori infection is considered to be a type I carcinogen and as the strongest known risk factor of gastric cancer (58).”
Gastric cancer: a comprehensive review of current and future treatment strategies (2020, background): “pylori can also secrete peptidoglycan into the host’s cell, which causes upregulation of various pro inflammatory cytokines such as IL-8 and COX leading to chronic inflammation and cancer development (18).”
Helicobacter pylori-induced gastric inflammation and gastric cancer. (2014, background): “Studies have shown that CagA could activate the hepatocyte growth factor/scatter factor receptor c-Met and adaptor protein Grb2 [20], induce phosphorylation of phospholipase C gamma (PLCc) and impair the E-cadherin/b-catenin complex formation in a CagA-independent manner [21,22].”