IL‐17: prototype member of an emerging cytokine family

By S. Aggarwal, A. Gurney. Journal of Leukocyte Biology, 2002

647 citations recorded by the source corpus.

IL‐17 is a potent proinflammatory cytokine produced by activated memory T cells. The large‐scale sequencing of the human and other vertebrate genomes has revealed the presence of additional genes encoding proteins clearly related to IL‐17, thus defining a new family of cytokines. There are at least six members of the IL‐17 family in humans and in mice. Initial characterization suggests that like IL‐17, several of these newly identified molecules have the ability to modulate immune function. Neither the IL‐17 family nor the cognate receptors that have been identified for these molecules bear obvious sequence similarity to other known families of proteins. Thus, they represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution. The potent inflammatory actions that have been identified for several of these factors and the emerging associations with major human diseases suggest that these proteins may have significant roles in inflammatory processes.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/7bc15b895a6c76714e912bcbb839dea35ab80c34

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Cua
2. V. Kuchroo
3. T. Korn
4. M. Oukka
5. R. Kastelein
6. E. Bettelli
7. T. Mcclanahan
8. W. Blumenschein

In Oncology

1. V. Kuchroo
2. D. Cua

In Pathology and Forensic Medicine

1. D. Cua
2. V. Kuchroo
3. T. Korn
4. E. Bettelli
5. M. Oukka
6. R. Kastelein

Citations in the corpus

• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation (2005, background): “Engagement of IL-17 and/or IL-17F on these cell types promotes expression of IL-1, IL-6, IL-8, TNF, and ICAM-1, which are all critical factors that drive inflammation (34).”
• Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. (2004, neutral): “tem, because of its unique effects [14].”
• IL-17 and Th17 Cells. (2009, background): “131 IL-17F KO mice (normal levels of IL-17A).”