Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter

By Andreas Heinz, D. Braus, M. Smolka, Jana Wrase, I. Puls, D. Hermann, Sabine Klein, S. Grüsser, Herta Flor, G. Schumann and 2 more. Nature Neuroscience, 2005

713 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/7b6a8b0c049fe5254f6c512127b2dd453a9272e7

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Epigenetics and the biological definition of gene x environment interactions. (2010, background): “Similar effects of the 5-HTTP promoter polymorphism are obtained in subjects during processing of negative relative to neutral pictures (Heinz et al., 2005) or words (Canli et al., 2006).”
A biosocial developmental model of borderline personality: Elaborating and extending Linehan's theory. (2009, background): “Findings also suggest an association between the amygdala–prefrontal circuit and genetic variations in the serotonin transporter (Heinz et al., 2004).”
Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. (2007, background): “In fact, there is already evidence amassing that the amygdala response to emotional face processing is moderated by genetic factors such as functional variation in the serotonin transporter, (46, 48, 65, 73, 74) raising the possibility that this particular endophenotype may well lend itself to furth”
Event-Related Potentials, Emotion, and Emotion Regulation: An Integrative Review (2010, background): “, 2005) and the ventromedial prefrontal cortex (Heinz et al., 2005).”
Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. (2008, methodology): “Although only one study (40) reported summary statistics separately for left and right hemisphere amygdala activation, these data were available for an additional two studies (39, 43).”
Functional Connectivity of the Human Amygdala using Resting State fMRI (2008, methodology): “The current study delineated patterns of connectivity that have been shown to be altered in clinical populations using task-based methods (Heinz et al., 2005;McClure et al., 2007; Pezawas et al., 2005; Quirk and Gehlert, 2003).”
Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. (2008, positive): “Such positive amygdala– ventrolateral prefrontal cortex connectivity has been observed previously in various populations and age groups studied with the standard approach used herein.(34,50) Differences in the approaches of these 2 connectivity procedures may provide insight into the discrepant find”
Two Genes Predict Voter Turnout (2008, neutral): “Once the ‘‘reuptake’’ of serotonin is complete and it is back inside the neuron, an enzyme called monoamine oxidase A (MAOA) degrades the serotonin so that its components can be reabsorbed in the cell.”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “…during emotional processing have been reported in humans carrying the short 'S' allele for the serotonin transporter gene (Pezawas et al, 2005; Heinz et al, 2005) and in mutant mice lacking this gene (Wellman et al, 2007), suggesting that there may be a genetic component underlying individual…”
Valence is a basic building block of emotional life (2006, background): “For example, people who carry a speciWc allele of the human serotonin transporter gene (SLC6A4) show stronger activation of the amygdala and medial prefrontal cortex when they are shown aversive pictures and faces with negative facial conWgurations (Hariri et al., 2002; Heinz et al., 2005).”
The self-regulating brain: Cortical-subcortical feedback and the development of intelligent action (2007, background): “In this case a trajectory of anxiety and depression can become entrenched as connections between the amygdala and ventral ACC are reinforced (Heinz et al., 2005) and those between dorsal ACC and the amygdala are attenuated.”
Tools of the trade: psychophysiological interactions and functional connectivity. (2012, result): “Approach (a) has been used, for example to compare carriers of genetic variations of a serotonin transporter (Heinz et al., 2005), and to compare schizophrenic patients to healthy controls (Boksman et al.”
Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies (2009, background): “For instance, reduced gray matter volume in the amygdala is more pronounced in those subjects carrying the s-allele of the serotonin transporter promoter polymorphism [Heinz et al., 2005; Pezawas et al., 2005].”