Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.

By Marcus Munafò, Sarah Marie Brown, Ahmad R. Hariri. Biological Psychiatry, 2008

840 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Epidemiology

View Paper: https://www.semanticscholar.org/paper/9bd49ac6c0f6676eda038963d10377ac774e47f9

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Epidemiology

Citations in the corpus

Psychobiology and molecular genetics of resilience (2009, positive): “These findings were confirmed in another recent meta-analysis, with this polymorphism accounting for up to 10% of phenotypic varianc”
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function (2010, background): “However, convergent evidence (90, 91) indicates that the higher penetrance of genetic variation at the level of intermediate neural phenotypes allows detection of genetic effects at sample sizes as low as 80 participants, a sample size well below the one studied here.”
The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-Analysis Revisited: Evidence of Genetic Moderation (2011, result): “In addition, our results are consistent with a wide range of experimental neuroscience studies that have found increased stress reactivity among 5-HTTLPR s allele carriers.(87-89) Evidence from animal studies also supports that functional variation in the serotonin transporter (SERT) gene affects be”
The evolution of the cognitive model of depression and its neurobiological correlates. (2008, background): “Hyperreactivity of the amygdala in the short 5-HTTLPR variant carriers is associated with increased sensitivity to negative stimuli (45) and leads to negative bias in the processing or interpretation of emotional stimuli (46, 47).”
A Heuristic for Developing Transdiagnostic Models of Psychopathology (2011, background): “These genetic abnormalities may lead to neuroticism or negative affectivity in part by creating chronic neural hyperreactivity to emotional and threat stimuli (Munafo et al., 2008).”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, neutral): “…two copies of the s allele also exhibit traits of anxiety (Lesch et al., 1996), increased risk to develop depression after tryptophan depletion (Neumeister et al., 2002), and increased amygdala responses to frightening faces (Hariri et al., 2002, 2005; Pezawas et al., 2005; Munafò et al., 2007 ).”
The brain basis of emotion: A meta-analytic review (2012, background): “…evidence suggests that the serotonin transporter gene (5-HTTLPR) – known to regulate neurotransmission within the amygadala and other regions supporting emotional vigilance (Munafo et al. 2008) – may have co-evolved along with cultural values of individualism–collectivism (Chiao & Blizinsky 2010).”
Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene (2009, background): “…from imaging genetics demonstrates that individuals carrying the S allele show greater amygdala response to emotional stimuli (Hariri et al. 2002; Munafò et al. 2008), which is likely due to increased amygdala resting activation (Canli et al. 2005) and decreased functional coupling between the…”
Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. (2012, neutral): “However, not all were able to replicate a significant interaction and some meta-analyses reported negative results (Munafo et al., 2008a, 2008b; Risch et al., 2009).”