Increased amygdala and insula activation during emotion processing in anxiety-prone subjects.

By Murray B. Stein, A. Simmons, Justin S. Feinstein, Martin P. Paulus. American Journal of Psychiatry, 2007

877 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/591f62081b72a1a82e5cd8ad145cb359b74fc53c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Experimental and Cognitive Psychology

Citations in the corpus

Regulation of anterior insular cortex activity using real-time fMRI (2007, background): “Insula hyperactivity seems to be a common feature in persons with elevated trait anxiety (Simmons et al., 2006; Stein et al., 2007).”
Interoception in anxiety and depression (2010, background): “Anxiety-prone relative to comparison subjects show greater bilateral amygdala and insula activation to emotional faces (Stein et al. 2007).”
Patterns of Emotional Reactivity and Regulation in Children with Anxiety Disorders (2010, background): “…individuals was recently demonstrated in functional magnetic resonance measures of blood oxygen level dependent responses in the amygdala (which is thought to be involved in threat detection) when anxious participants were shown threatening images (Phan et al. 2006; Stein et al. 2002, 2007).”
Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder (2011, background): “Furthermore, both patients with social anxiety and panic disorder comprise similar pathological networks (Cannistraro and Rauch, 2003; Milad and Rauch, 2007) and exhibit the same neurochemical dysfunctions (Lanzenberger et al., 2007; Nash et al., 2008; Neumeister et al., 2004).”
Mesocorticolimbic Circuits are Impaired in Chronic Cocaine Users as Demonstrated by Resting State Functional Connectivity (2010, positive): “Finally, seeds in the rACC demonstrated decreased connectivity in CU subjects with the insula and amygdala, areas important for emotional functioning (Stein et al., 2007).”
Selective aberrant functional connectivity of resting state networks in social anxiety disorder (2010, background): “We argue that persistent hyperactivity of the insula of anxiety patients when the neural correlates of a current fear or anxiety state or a trait vulnerability for excessive fear responses (Etkin et al., 2009; Stein et al., 2007) would disrupt functional connectivity from insula to other brain syste”
Gastric distention activates satiety circuitry in the human brain (2008, neutral): “The anterior insula has been implicated with integration of emotion, behavior (Jabbi et al., 2007; Stein et al., 2007) and perception of pain (reviewed) (Craig, 2002).”
Human Insula Activation Reflects Risk Prediction Errors As Well As Risk (2008, result): “This view is further corroborated by studies that have suggested the involvement of insula in risk aversion (Kuhnen and Knutson, 2005; Rolls et al., 2008) and anxiety (Stein et al., 2007).”
Saliency, switching, attention and control: a network model of insula function (2010, neutral): “For example, AI hyperactivity has been implicated in anxiety disorders, suggesting that when the SN goes into overdrive, pathology subsequently results (Paulus and Stein 2006; Stein et al. 2007).”
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (2007, background): “Additional evidence for our argument comes from a recent study of “anxiety-prone” individuals, which noted both amygdalar and insular hyperactivity (92).”
The influence of negative emotions on pain: Behavioral effects and neural mechanisms (2009, neutral): “…of unpleasant stimuli activates right insular cortex (Simmons et al., 2004), that anxiety-prone individuals have bilaterally increased insula activation during emotion processing (Stein et al., 2007), and that anterior insula activation can be attenuated by an anxiolytic drug (Paulus et al., 2005).”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “…studies have not reported exaggerated amygdala activation in specific phobia (Hermann et al, 2007; Larson et al, 2006; Paquette et al, 2003; Straube et al, 2004b, 2007; Wik et al, 1996, 1997; Wright et al, 2003), perhaps in part due to methodological differences, such as the use of…”