Nod2 is required for the regulation of commensal microbiota in the intestine
By Tanja Petnicki‐Ocwieja, T. Hrncír, Yuen-Joyce Liu, A. Biswas, T. Hudcovic, H. Tlaskalova-Hogenova, Koichi S. Kobayashi. Proceedings of the National Academy of Sciences of the United States of America, 2009
604 citations recorded by the source corpus.
Subfields: Genetics, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d121b68f94a496d302b3ba4a849a239c88717100
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Citations in the corpus
- Current understanding of dysbiosis in disease in human and animal models (2016, result): “In NOD22/2 mice, an altered gut microbiota was seen in the terminal ileal mucosa, mostly consisting of an increase of Bacteroides and Firmicutes compared with NOD2 WT mice, which had barely detectable amounts of these bacteria genera.(68,72) These data also correlates to what was seen in humans cont”
- Mechanisms and consequences of intestinal dysbiosis (2017, background): “The NOD2 receptor, expressed in monocytes and Paneth cells [134], regulates commensal gut community by restricting the number of bacteria and the colonization by pathogens, especially in the terminal ileum [135].”
- Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Furthermore, Nod2-deficient mice abolished the capability of preventing pathogenic bacterial colonization from intestine [188].”
- Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, background): “Thus, mice lacking the bacterial sensing receptor nucleotide-binding oligomerisation domain-containing protein-2 showed significantly more Bacteroidetes as well as Firmicutes compared with wild-type mice.(58) Modulation of the microbiota induces visceral hypersensitivity in mice, which is reduced by”
- Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “The impact of the NOD2 gene on microbial regulation has been addressed in an NOD2 gene knock-out mouse model that showed a highly persistent overgrowth of the pathogenic bacterial species Helicobacter hepaticus [181].”
- Pathological bacterial translocation in liver cirrhosis. (2014, background): “Indeed, MDP induces bacterial killing in vitro in ileal crypts and intestinal crypts lacking NOD2 are unable to kill bacteria efficiently [174].”
- Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut (2015, background): “In intestinal mucosa, the lack of feedback between mutated NOD2/CARD15 expression and gut luminal microbiota can lead to the breakdown of tolerance [73].”
- Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis (2011, background): “and help shape the composition of the indigenous microbiot”