The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

By Xiang-Jiao Yang, E. Seto. Nature reviews. Molecular cell biology, 2008

1,254 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d8121bf6935284764f08d1ea100e3d83eabbec08

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Citations in the corpus

HDAC family: What are the cancer relevant targets? (2009, background): “Hdac7 is specifically expressed in the vascular endothelium during early embryogenesis, where it maintains vascular integrity by repressing the expression of matrix metalloproteinase 10 by associating with myocyte enhancer factor-2 (MEF2) [32].”
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes (2011, background): “Whereas the CoREST, NuRD and Sin3 complexes contain an HDAC1-HDAC2 dimer as core, the NCoR complex is formed around HDAC3 (ref”
The many roles of histone deacetylases in development and physiology: implications for disease and therapy (2009, background): “The class I HDAC family consists of HDAC1, 2, 3 and 8, which share homology with Rpd3 — a founding member from budding yeas”
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, neutral): “Mammalian HDACs have been classified into four classes based on their structure and regulation (Yang and Seto, 2008).”
Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex (2015, background): “The Sin3/Rpd3 complexes are ancient, with the core subunits conserved in organisms in the fungal, plant, and animal kingdoms (1, 8).”
Sirt1 and the Mitochondria (2016, background): “In mammals, HDACs are broadly divided into four classes (I-IV) (Yang and Seto, 2008).”
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes (2009, methodology): “…into four classes: class I (HDAC1, 2, 3, and 8 with a homology to Rpd3), class II (HDAC4, 5, 6, 7, 9, and 10 with a homology to Hda1), class III (Sirt1, 2, 3, 4, 5, 6, and 7 with a homology to Sir2), and class IV (HDAC11) (de Ruijter et al., 2003; Yang and Gregoire, 2005; Yang and Seto, 2008).”
Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “prenatally with severe proliferation defects and general growth retardation; HDAC2-null mice die the first day after birth for cardiac malformations; and HDAC3-null mice die prenatally for defects in gastrulation [3,4].”