Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

By B. Meresse, Zhangguo Chen, C. Ciszewski, M. Tretiakova, G. Bhagat, T. Krausz, D. Raulet, L. Lanier, V. Groh, T. Spies and 3 more. Immunity, 2004

889 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/53a32217d0689061d04f2e9ffa910812e22a2a32

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In Immunology

1. L. Lanier
2. D. Raulet
3. S. Gasser
4. W. Deng
5. Heiyoun Jung
6. Benjamin G. Gowen
7. Hilde Cheroutre
8. Sylvia M. Lee

Citations in the corpus

• The light and dark sides of intestinal intraepithelial lymphocytes (2011, positive): “In this setting, TCR-activated CD8αβ + TCRαβ + induced IELs cause severe villous atrophy by targeting intestinal epithelial cells that express stress-induced MHC class I polypeptide-related sequence (MIC) antigens, in an NKG2D-dependent fashio”
• Regulation of ligands for the NKG2D activating receptor (2013, background): “In some scenarios, such as after potent activation of human CD8+ T cells with IL15 and CD3 engagement, subsequent NKG2D engagement in the absence of T cell receptor activation is sufficient to trigger target cell killing (18).”
• Up on the tightrope: natural killer cell activation and inhibition (2008, background): “Similarly, the ability of human CD8 + T cells to kill when activated through the NKG2D receptor also requires previous stimulation by high concentrations of IL-2 or IL-15 (ref”
• Wheat seed storage proteins: Advances in molecular genetics, diversity and breeding applications (2014, background): “In addition to the adaptive CD4þ T cell response to gluten, CD is characterized by upregulation of IL-15, an intraepithelial T cell infiltrate expressing the NKG2D receptor, and the overexpression of a ligand for NKG2D (MICA) (Meresse et al., 2004).”
• CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin (2017, neutral): “lymphocyte responses that turn pathological in celiac disease (Meresse et al., 2004).”
• Cytokines in Cancer Immunotherapy (2011, background): “These effects are mediated through direct activation of CD8+ effector T cells in an antigenindependent manner [103].”