The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
By C. Brandt, M. Baratin, E. Yi, J. Kennedy, Zeren Gao, Brian A. Fox, B. Haldeman, Craig D. Ostrander, T. Kaifu, Christian Chabannon and 5 more. Journal of Experimental Medicine, 2009
688 citations recorded by the source corpus.
Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate immune system that participate in the elimination of tumors. We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion. This previously unannotated gene belongs to the B7 family and, hence, was designated B7-H6. B7-H6 triggers NKp30-mediated activation of human NK cells. B7-H6 was not detected in normal human tissues but was expressed on human tumor cells, emphasizing that the expression of stress-induced self-molecules associated with cell transformation serves as a mode of cell recognition in innate immunity.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/dd49b31bfb491d1535313210398b6ffe4ecd217e
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In Immunology
Citations in the corpus
- Targeting natural killer cells and natural killer T cells in cancer (2012, background): “An exception resides in the identification of a new member of the B7 family of immunoreceptors, B7-H6, as a cellular ligand for NKp30 (Ref”
- Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “The only transmembrane protein, normally expressed at the plasma membrane, that has been identified as a ligand for an NCR is B7H6, which binds to NKp30 and is expressed on several tumor cell lines (24).”