Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

By T. Wilkinson, C. Li, Cecilia Chui, A. Huang, Molly R. Perkins, Julia C Liebner, Rob Lambkin-Williams, A. Gilbert, J. Oxford, Ben Nicholas and 5 more. Nature Medicine, 2012

974 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/ae6f2daa3aa57120ed89c59b58458703aa7f9449

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Citations in the corpus

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020, background): “seen in influenza virus infection[19], we did not observe significant differences in the”
Potent Protection against H5N1 and H7N9 Influenza via Childhood Hemagglutinin Imprinting (2016, background): “This parallels the reduced severity observed for repeat infections with seasonal strains (22,23,25).”
Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, positive): “Given that T cell memory has a role in protection from influenza disease severity in humans (Greenbaum et al., 2009; Sridhar et al., 2013;Wilkinson et al., 2012), and with the evidence described above for SARS-CoV-2 T cells, it seems unlikely that T cell memory would not have some protective…”
COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning (2020, background): “Instead, T cell responses are often long-lived by targeting conserved proteins and showed to have a significant correlation in protective immunity against influenza virus infection (32).”
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals (2020, positive): “The presence of cross-reactive T cells was found to correlate with less severe disease (Sridhar et al., 2013; Wilkinson et al., 2012).”
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications (2020, background): “The high and even increasing activated or proliferating CD8 and CD4 T cell responses over ~1 week during acute viral infection contrasted with the sharp peak of KI67 in CD8 and CD4 T cells during acute viral infections, including smallpox vaccination with live vaccinia virus (47), live attenuated ye”
IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection (2017, background): “410 Wilkinson et al also found an inverse correlation between CD4+ cells and patient symptoms 411 following viral challenge [51], suggesting an important role of CD4+ cytotoxic activity in 412 response to influenza infection.”
Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia (2020, background): “groups dominance in different periods of infection should be explored further, but the CD4+ T lymphocyte counts have been linked to disease severity [28,29].”