Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb.

By M. Yokoi, K. Mori, S. Nakanishi. 1995

Mitral/tufted cells (M/T cells) and granule cells form reciprocal dendrodendritic synapses in the main olfactory bulb; the granule cell is excited by glutamate from the M/T cell and in turn inhibits M/T cells by gamma-aminobutyrate. The trans-synaptically excited granule cell is thought to induce lateral inhibition in neighboring M/T cells and to refine olfactory information. It remains, however, elusive how significantly and specifically this synaptic regulation contributes to the discrimination of different olfactory stimuli. This investigation concerns the mechanism of olfactory discrimination by single unit recordings of responses to a series of normal aliphatic aldehydes from individual rabbit M/T cells. This analysis revealed that inhibitory responses are evoked in a M/T cell by a defined subset of odor molecules with structures closely related to the excitatory odor molecules. Furthermore, blockade of the reciprocal synaptic transmission by the glutamate receptor antagonist or the gamma-aminobutyrate receptor antagonist markedly suppressed the odor-evoked inhibition, indicating that the inhibitory responses are evoked by lateral inhibition via the reciprocal synaptic transmission. The synaptic regulation in the olfactory bulb thus greatly enhances the tuning specificity of odor responses and would contribute to discrimination of olfactory information.

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “The most abundant of these are granule cells, which are thought to enhance odour tuning through lateral inhibition (Yokoi et al., 1995; Arevian et al., 2008; Giridhar et al., 2011).”
Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal Behavior (2010, unknown): “…than preexisting cells (Magavi et al., 2005), and because interneurons are thought to play an important role in the discriminability of odors (Yokoi et al., 1995; Abraham et al., 2010), we hypothesized that the addition of newly generated neurons that are reaching maturity at the time of…”
Is adult neurogenesis essential for olfaction? (2011, unknown): “10 Yokoi, M. et al. (1995) Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb.”
Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain. (2003, background): “At higher fine the response of projection neurons to different odor concentrations that are likely to exceed those enodors (Imamura et al., 1992; Laurent and Naraghi, 1994; countered in natural environment, several glomeruli ap- Yokoi et al., 1995).”
Adult-born neurons facilitate olfactory bulb pattern separation during task engagement (2018, unknown): “In normal animals, excitatory inputs from sensory neurons combined with local inhibitory control would allow MCs to respond to odorants in both excitatory and suppressive manners (Yokoi et al., 1995).”
Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry. (2001, background): “The first is a lateral inhibition between glomerular groups that can enhance the specificity of responses within groups of similar compounds (Yokoi et al., 1995).”
Parvalbumin-expressing interneurons linearly control olfactory bulb output (2013, unknown): “This circuit offers a basis for interglomerular inhibition that has been suggested to sharpen mitral cell odor tuning and enhance the contrast of odor representations (Yokoi et al., 1995) or, alternatively, act more generally as a gain control mechanism regulating the dynamic range of mitral cell ac”
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, unknown): “This inhibition helps enhance contrast between similar inputs (Luo andKatz, 2001; Schoppa andUrban, 2003; Yokoi et al., 1995) and thus enhances separation between similar patterns of olfactory sensory neuron input (Figure 2).”
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. (2007, background): “Whereas several studies indicate that lateral inhibition within and between glomeruli shapes activity in the olfac- tory bulb (Yokoi et al., 1995; Luo and Katz, 2001; Aungst et al., 2003; Urban, 2002; Tabor et al., 2004), others have not observed significant interactions between activated glomeruli…”
Impaired odour discrimination on desynchronization of odour-encoding neural assemblies (1997, background): “Because picrotoxin affected the behavioural discrimination of similar alcohols, this effect could simply be due to a picrotoxin-induced loss of odour specificity (rather than desynchronization) of the projection neurons representing these alcohol”
Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction (2002, background): “Granule cells are known to extensively shape mitral cell response to odors (Yokoi et al., 1995), and there is evidence that the OB circuitry does maximize differences in odor representations (Friedrich and Laurent, 2001).”
Non-topographical contrast enhancement in the olfactory bulb (2006, methodology): “NTCE was able to replicate the contrast enhancement function within model mitral cells based on periglomerular inhibition alone (Figure 6A; compare with Figure 2A in reference [10]).”
Organization of antennal lobe‐associated neurons in adult Drosophila melanogaster brain (2012, background): “The function of the granule cells has been suggested to be related to the lateral inhibition of PNs in neighboring glomeruli (Yokoi et al., 1995) and the generation of synchronized spike timing of mitral cells (Schoppa, 2006), whereas those of the periglomerular neurons remains unclear.”
Critical period regulation. (2004, background): “The new neurons are GABAergic granule cells, which sharpen the evoked pattern of neural activity through lateral inhibition of mitral cells (Yokoi et al. 1995).”
Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb (2014, unknown): “…prominently observed in M/TCs in anesthetized animals have for decades been linked to this idea, fuelled by the observation that some odorants, which are structurally similar to odorants that excite a recorded M/TC, can inhibit them 20 , reminiscent of a “centre-surround” arrangement 20,21 .”