Parvalbumin-expressing interneurons linearly control olfactory bulb output

By Hiroyuki K. Kato, S. Gillet, Andrew J. Peters, Jeffery S. Isaacson, Takaki Komiyama. 2013

175 citations recorded by the source corpus.

SUMMARY In the olfactory bulb, odor representations by principal mitral cells are modulated by local inhibitory circuits. While dendrodendritic synapses between mitral and granule cells are typically thought to be a major source of this modulation, the contributions of other inhibitory neurons remain unclear. Here we demonstrate the functional properties of olfactory bulb parvalbumin-expressing interneurons (PV cells) and identify their important role in odor coding. Using paired recordings, we find that PV cells form reciprocal connections with the majority of nearby mitral cells, in contrast to the sparse connectivity between mitral and granule cells. In vivo calcium imaging in awake mice reveals that PV cells are broadly tuned to odors. Furthermore, selective PV cell inactivation enhances mitral cell responses in a linear fashion while maintaining mitral cell odor preferences. Thus, dense connections between mitral and PV cells underlie an inhibitory circuit poised to modulate the gain of olfactory bulb output.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Broadly tuned inhibition from parvalbumin-expressing interneurons could also mediate gain control of mitral cell responses (Kato et al., 2013).”
Purkinje cells directly inhibit granule cells in specialized regions of the cerebellar cortex (2016, unknown): “This contrasts with other areas in the brain where principle neurons often recruit interneurons to regulate local excitability and gain (Bortone et al., 2014; Freund and Buzsá ki, 1996; Kato et al., 2013; Olsen et al., 2012; Sik et al., 1994).”
Unsupervised Discovery of Demixed, Low-Dimensional Neural Dynamics across Multiple Timescales through Tensor Component Analysis (2017, background): “Such trial-to-trial ﬂuctuations in amplitude have been observed in a variety of sensory systems [22, 35–37], and are believed to be an important and ubiquitous feature of cortical circuits [30, 31].”
Inhibitory circuits of the mammalian main olfactory bulb. (2017, background): “EPL-INs form both reciprocal and nonreciprocal synapses exclusively with M/TCs (Huang et al. 2013; Kato et al. 2013; Lepousez et al. 2010; Toida et al. 1994, 1996), including basketlike innervation of some M/TC somata (Crespo et al. 2002, 2013; Kosaka and Kosaka 2008b), which likely functions…”