In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2.

By Benjamin R. Arenkiel, J. Peça, I. Davison, C. Feliciano, Karl Deisseroth, G. Augustine, Michael D. Ehlers, G. Feng. Neuron, 2007

770 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/6559b334e7cddc80bb8a37556b242ed54a6f5ad2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

In Sensory Systems

Citations in the corpus

Molecular and cellular approaches for diversifying and extending optogenetics. (2010, background): “…to substantial versatility of the optogenetic approach across animal species (Adamantidis et al., 2007; Airan et al., 2009; Aravanis et al., 2007; Arenkiel et al., 2007; Bi et al., 2006; Boyden et al., 2005; Chow et al., 2010; Douglass et al., 2008; Gradinaru et al., 2008, 2009; Hägglund et…”
Optogenetic investigation of neural circuits underlying brain disease in animal models (2012, background): “and transgenic rodent lines that increase the range of available specific cellular target”
Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity (2012, positive): “Slices Acute slices (250–300 mm thick) were prepared from the cerebellar vermis of postnatal day (P)17–20 Sprague Dawley rats, P19–29 Thy1-ChR2/EYFP line 18 mice (Jackson Laboratory) (Arenkiel et al., 2007), and Prv-mhChR2/EYFP mice (Jackson Laboratory) (Zhao et al.”
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity (2013, background): “The absence of spike latencies shorter than ~9 ms suggests that this is the time it takes to discharge a ChR2-expressing principal cell by direct optical stimulation under the conditions described herein (36).”
Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance (2015, neutral): “2 promoter in randomly integrated transgenes (Arenkiel et al., 2007; Dana et al., 2014; Feng et al., 2000; Zhao et al., 2008), presumably with multiple copies at the insertion site.”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, positive): “selectively targeted the light-activated gene channelrhodopsin-2 (ChR2) (Arenkiel et al., 2007; Boyden et al., 2005; Zhang et al., 2006; Zhang et al., 2007) to DA neurons via the tyrosine hydroxylase gene in Cre transgenic animals with local injection of adenoassociated virus.”
The Development and Application of Optogenetics (2011, methodology): “The first transgenic opsin-expressing mouse line was generated using the Thy1 promoter (Arenkiel et al. 2007, Zhao et al. 2008), with widespread expression throughout neocortical layer 5 projection neurons as well as in some subcortical structures (Arenkiel et al. 2007).”
Genetic dissection of neural circuits. (2008, positive): “ChR2 has already allowed fast optical control of genetically targeted neuronal populations in vivo (Nagel et al., 2005; Schroll et al., 2006; Arenkiel et al., 2007; Suh et al., 2007).”
The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. (2009, background): “…remarkable technical progress is being made toward largescale, high-resolution analysis of synaptic circuits (Nikolenko et al., 2007; Nagel et al., 2003; Boyden et al., 2005; Arenkiel et al., 2007; Petreanu et al., 2007; Wang et al., 2007; Briggman and Denk, 2006; Wickersham et al., 2007).”