Licensing of natural killer cells by host major histocompatibility complex class I molecules

By Sungjin Kim, Jennifer Poursine‐Laurent, S. Truscott, L. Lybarger, Yun-jeong Song, Liping Yang, A. French, J. Sunwoo, S. Lemieux, T. Hansen and 1 more. Nature, 2005

1,374 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/796018bafe3b6f2f542d47f09d99b04284186e14

How researchers see this paper

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In Immunology

1. A. Steinle
2. I. Waldhauer
3. É. Vivier
4. D. Raulet
5. S. Ugolini
6. R. Vance
7. Eric O Long
8. Chao Yang

Citations in the corpus

• NK cells and cancer immunosurveillance (2008, background): “NK cells that do not express at least one inhibitory receptor matching the own MHC class I outfit are hyporesponsive (Kim et al., 2005; Anfossi et al., 2006).”
• Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, background): “Together with data from other groups demonstrating that NK cells undergo an education process that has been compared by some to ‘‘positive selection’’ of T cells (Anfossi et al., 2006; Fernandez et al., 2005; Kim et al., 2005), and a recent report indicating that NK cells are capable of immunologica”
• Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 (2007, result): “This model is consistent with recent studies implicating inhibitory receptors for MHC class I in the education and eventual killing capacity of NK cell”
• The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “The fact that NK cell education does not require SHP-1 and SHIP-1 phosphatases suggests that inhibitory signals are indispensable for NK cell education and supports arming model (115).”
• The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation (2012, background): “…that Eomes and Eomes+ NK cells expressed NKG2A (Figure S5E) and Ly49C and/or Ly49I (Figure 1F), which bind MHC class I ligands in C57BL/6 mice (Brennan et al., 1996a, 1996b; Liu et al., 2000) and arm or license NK cells to kill targets (Kim et al., 2005; Raulet and Vance, 2006; Vance et al., 1998).”
• T cell– and B cell–independent adaptive immunity mediated by natural killer cells (2006, background): “A study of C57BL/6 and C57BL/10 mice has shown that NK cells expressing Ly49C, a cognate inhibitory receptor for self major histocompatibility complex (MHC) class Ia molecules, are uniquely able, relative to other NK cells, to exert effector activity in response to a variety of stimul”
• Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “Similarly, NKG2A, LIR-1, and mouse Ly49 receptors also contain cytoplasmic ITIMs that are capable of recruiting SHP-1 (28).”
• Functions of natural killer cells (2008, background): “This education process requires the recognition of self–MHC class I molecules by cognate inhibitory receptors, such as Ly49 molecules in mice and KIRs in human”
• Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “In 2005, Yokoyama and colleagues termed the widely accepted model of NK cell education as “licensing” (90) which proposes that phosphatase activation in response to the ITIMs found in inhibitory receptors ultimately controls NK cell responsiveness.”